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Abstract
Five awake dogs with Mann-Bollman fistulas each underwent six daily studies in which
50 ml of 20% glucose was infused intraduodenally (ID) over a period of 10 minutes.
In five of six studies, either gastrin, pentagastrin, cholecystokinin, secretin, or
glucagon was infused intravenously (IV) for 30 minutes before and 120 minutes after
ID administered glucose. Venous blood samples at 15-minute intervals were assayed
for immunoreactive gastric inhibitory peptide (GIP). IV administered gastrin, pentagastrin,
cholecystokinin, secretin, and glucagon had no effect on fasting immunoreactive GIP
(iGIP). Compared to fasting, iGIP was significantly (p < 0.05) increased at 15, 30,
and 45 minutes for all treatment groups. Compared to ID administered glucose alone,
the GIP response following either IV gastrin plus ID glucose, IV pentagastrin plus
ID glucose, or IV cholecystokinin plus ID glucose was significantly greater (p < 0.05)
at 5 and 15 minutes. This study demonstrates augmentation of glucose-stimulated GIP
by the structurally similar peptides; gastrin, pentagastrin, and cholecystokinin,
suggesting a physiological role for endogenous gastrin and cholecystokinin in modulating
the GIP response to glucose.
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References
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Sirinek, K. R.: Unpublished data
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Tetirick, C. E.: Unpublished data
Article info
Footnotes
☆Supported by a grant from the John A. Hartford Foundation, Inc., Columbus, Ohio.
☆☆Presented at the Thirty-fourth Annual Meeting of the Central Surgical Association, Buffalo, N. Y., March 3–5, 1977.
Identification
Copyright
© 1977 Published by Elsevier Inc.
