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Abstract
In a series of 89 patients operated for primary hyperparathyroidism in the last 12
years, 27 (30%) had a history of radiation therapy to the head and neck for benign
disease in infancy, childhood, adolescence or young adulthood: 13 male and 14 female
patients. In six patients the total administered radiation dose was known to range
between 300 and 750 rads (air). Thirteen patients had a single parathyroid adenoma
and 14 had parathyroid hyperplasia or multiglandular disease. Thyroid carcinoma was
associated with hyperparathyroidism in four patients, and six had benign thyroid tumors.
No discernible thyroid abnormality was present in the other 17 patients. A history
of radiation to the head and neck in a high proportion of patients with hyperparathyroidism,
both in conjunction with thyroid tumors and in the absence of thyroid pathology, suggests
that exposure of the parathyroids to radiation may play an etiologic role in the development
of hyperparathyroidism in some patients with this disease.
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Article info
Footnotes
☆Supported in part by the John A. Hartford Foundation, Inc.
☆☆Presented at the Thirty-fourth Annual Meeting of the Central Surgical Association, Buffalo, N. Y., March 3–5 1977.
Identification
Copyright
© 1977 Published by Elsevier Inc.
