Advertisement
Surgery
Advanced searchSave search
Central Surgical Association| Volume 82, ISSUE 3, P314-320, September 1977

Questionable value of furosemide in preventing renal failure

DOI:https://doi.org/10.5555/uri:pii:0039606077901386
Questionable value of furosemide in preventing renal failure
Previous ArticleAbdominoperineal resection in the treatment of devascularizing rectal injuries
Next ArticleCarotid endarterectomy: Is an indwelling shunt necessary?
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      The effects of furosemide on renal function and hemodynamics were evaluated in 54 critically ill surgical patients. Standard clearance techniques were used to measure glomerular filtration rate (GFR), renal plasma flow (RPF), osmolar clearance (COsm), sodium clearance (CNa), and renal blood flow (RBF). RBF distribution to outer cortex, inner cortex-outer medulla, and inner medulla was measured by the radioactive xenon disappearance technique. Furosemide produced a marked rise in urine output, COsm, and CNa; it produced no change in GFR, RPF, RBF, and RBF distribution. Twelve of the 54 patients received furosemide for therapy not related to the study; six patients developed renal failure and five became hypotensive 2 to 10 hours after administration of furosemide. These data demonstrate that furosemide does not protect against renal failure by altering or increasing RBF but may cause renal failure by producing hypovolemia.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Bailey R.R.
        • Natale R.
        • Turnbull D.I.
        Protective effect of furosemide in acute tubular necrosis and acute renal failure.
        Clin Sci. 1973; 45: 1
        • Birtch A.G.
        • Zakheim R.M.
        • Jones L.G.
        • et al.
        Redistribution of renal blood flow produced by furosemide and ethacrynic acid.
        Circ Res. 1967; 21: 869
        • Bradley V.E.
        • Shier M.R.
        • Lucas C.E.
        • et al.
        Renal hemodynamic response to furosemide in septic and injured patients.
        Surgery. 1976; 79: 549
        • Brown J.J.
        • Gleadle R.I.
        • Lawson D.H.
        • et al.
        Renin and acute renal failure: studies in man.
        Br Med J. 1970; 1: 253
        • Flamenbaum W.
        Pathophysiology of acute renal failure.
        Arch Intern Med. 1973; 131: 911
        • Hayes D.F.
        • Werner M.H.
        • Rosenberg I.K.
        • et al.
        Effects of traumatic hypovolemic shock on renal function.
        J Surg Res. 1974; 16: 490
        • Ledgerwood A.M.
        • Lucas C.E.
        Postresuscitation hypertension: Etiology, morbidity and treatment.
        Arch Surg. 1974; 108: 531
        • Linton A.L.
        Acute renal failure.
        Canad Med Assoc J. 1972; 110: 949
        • Lucas C.E.
        The renal response to acute injury and sepsis.
        Surg Clin North Am. 1976; 56: 953
        • Lucas C.E.
        • Rector R.E.
        • Werner M.
        • et al.
        Altered renal homeostasis with acute sepsis: A clinical significance.
        Arch Surg. 1973; 106: 444
        • Ludens J.H.
        • Hook J.B.
        • Brody M.J.
        • et al.
        Enhancement of renal blood flow by furosemide.
        J Pharmacol Exp Ther. 1968; 163: 456
        • Ochoa E.
        • Finkielman S.
        • Agrest A.
        Angiotension blood levels during the evolution of acute renal failure.
        Clin Sci. 1970; 38: 225
        • Rosenberg I.K.
        • Gupta S.L.
        • Lucas C.E.
        • et al.
        Renal insufficiency after trauma and sepsis: A prospective functional and ultrastructural analysis.
        Arch Surg. 1971; 103: 175
        • Smith H.W.
        Principles of renal physiology.
        Oxford University Press, New York1956
        • Stott R.B.
        • Cameron J.S.
        • Ogg S.C.
        • et al.
        Why the persistently high mortality rate in acute renal failure?.
        Lancet. 1972; 2: 75
        • Stone A.M.
        • Stahl W.M.
        Effect of ethacrynic acid and furosemide on renal function in hypovolemia.
        Ann Surg. 1971; 174: 1
        • Whelton A.
        • Donadio J.W.
        Posttraumatic acute renal failure in Vietnam: A comparison with Korean War experience.
        Johns Hopkins Med J. 1969; 124: 95
        • Zito J.
        • Cortez A.
        • Lucas C.E.
        • et al.
        The distribution of renal blood flow after furosemide in critically ill patients.
        in: ed. 14. Surg Forum. 27. 1976: 27

      Article info

      Footnotes

      ☆Supported by the Detroit General Hospital Research Corporation, Detroit, Mich.

      ☆☆Presented at the Thirty-fourth Annual Meeting of the Central Surgical Association, Buffalo, N. Y., March 3–5 1977.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606077901386

      Copyright

      © 1977 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX