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Abstract
Of one hundred and twenty-six patients with Gardner's syndrome, 60% showed soft tissue
tumors, 32% showed osteomatosis, 67% polyposis, and 20% the complete triad. Bowel
cancer developed in 32% of the patients. The frequency of other diseases in these
patients showed fibrous tumors in 8%, and two patients with cancer of the ampulla
of Vater; otherwise the diseases seen did not show any major variation from what might
be expected for the group at risk. Laboratory evaluation has included the demonstration
of increased fecal cholesterol and primary bile acids in these patients. The recommended
surgical treatment is colectomy and ileorectal anastomosis at a measured 12 cm level.
This level of ileorectal anastomosis may be vital in giving a regression of rectal
polyps, which was seen in 15 to 17 patients so treated. The conversion of an ileosigmoid
to an ileorectal anastomosis resulted in polyp regression in one patient. The oral
administration of ascorbic acid gave polyp regression in seven of 10 patients. There
may be a possible relationship of fecal coprostanol and cholesterol levels and polyp
regression
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References
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Article info
Footnotes
☆Supported by the Charleston Foundation for Cancer Research and the West Virginia Aerie Fraternal Order of the Eagles, W. Va.
☆☆Presented at the Thirty-fourth Annual Meeting of the Central Surgical Association, Buffalo, N. Y., March 3–5 1977.
Identification
Copyright
© 1977 Published by Elsevier Inc.
