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Abstract
Ten dogs have been used in a study which demonstrates the feasibility of producing
total pancreatic duct obstruction with alkyl-alpha-cyanoacrylate glue. Low pressure
injection of glue into the pancreatic duct has led to a reproducible pancreatic atrophy
with preservation of the islets. A sharp rise in serum amylase was noted in each dog,
but at autopsy examination at monthly intervals after the operation, no evidence of
chronic pancreatitis was observed. None of the dogs was rendered diabetic. The success
of the experimental technique raises the possibility that such a technique might be
useful in the management of human chronic pancreatitis as an alternative to pancreatic
resection, and the operation has been performed on three patients so far.
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Article info
Publication history
Accepted:
July 23,
1976
Identification
Copyright
© 1977 Published by Elsevier Inc.
