This paper is only available as a PDF. To read, Please Download here.
Abstract
The effects of abdominal operation on the antecubital vein plasma amino acid concentration
were examined. With four groups, each containing ten patients, factors such as severity
of surgical operation, anesthesia, and postoperative nutrition were examined. Immediately
after operation there is a fall in the plasma concentrations of most amino acids;
the nonessential amino acids (glutamate, proline, glycine, alanine, histidine, and
arginine) continue to fall during the 2 postoperative days, whereas the essential
amino acids (isoleucine, leucine, phenylalanine, and lysine, with tyrosine) are at
higher concentration at 48 hours than immediately after operation. Comparison of a
group of patients undergoing an operation of moderate severity (vagotomy and pyloroplasty
or cholecystectomy) with those having the more severe procedure of resection of aortic
aneurysm with Dacron graft replacement suggests that these general changes in amino
acid concentrations do not appear to be due to the severity of the operation, although
cystine levels were lower, and phenylalanine levels were higher, in the graft-replacement
group. The changes did not appear to be the result of anesthesia. Increasing the postoperative
glucose intake was associated with higher plasma alanine and lower methionine levels.
It is suggested that, in surgical patients, cystine and tyrosine may become essential
amino acids and rises in phenylalanine and methionine indicate transient liver dysfunction.
The data give support to the view that a high calorie intake after operation has a
beneficial effect.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Influence of dietary deprivations on plasma concentration of free amino acids of man.J. Appl. Physiol. 1968; 25: 52
- Oxidation of branched chain amino acids by isolated hearts and diaphragms of the rat. The effect of fatty acids, glucose, and pyruvate respiration.J. Biol. Chem. 1972; 247: 8085
- Observations on disturbance of metabolism produced by injury to limbs.Q. J. Med. 1932; 1: 233
- Effect of parenteral alimentation mixtures on plasma amino acid levels in adult subjects: Comparison of the route of administration.in: Fed. Proc. 31. 1972: 732
- Effect of surgery on plasma levels of individual essential amino acids.Surgery. 1952; 31: 226
- Changes in plasma amino acid nitrogen concentration following nitrous oxide and ether anesthesia and surgery.in: Proc. Soc. Exp. Biol. Med. 50. 1942: 256
- Amino acid metabolism during prolonged starvation.J. Clin. Invest. 1969; 48: 584
- Arterial plasma amino acids in patients receiving an elemental diet.in: Surg. Forum. 25. 1974: 54
- The effect of nutrition on nitrogen metabolism in the surgical patient.Ann. Surg. 1957; 146: 563
- The endocrine response to trauma.Adv. Clin. Chem. 1972; 15: 255
- The effect of intravenous feeding on the balances of nitrogen, sodium, and potassium after operation.Br. J. Surg. 1966; 53: 885
- Studies of plasma amino acids and amino conjugates in patients with severe battle wounds.Surg. Gynecol. Obstet. 1955; 101: 35
- Protein metabolism; disturbances under conditions of shock and surgical interference.Am. J. Surg. 1936; 32: 313
- Control of gluconeogenesis from amino acids in the perfused rat liver.J. Biol. Chem. 1969; 244: 5713
- Plasma α-amino acid nitrogen and serum lipids of surgical patients.J. Clin. Invest. 1946; 25: 701
- Positive nitrogen balance immediately after abdominal operations.Am. J. Surg. 1970; 119: 70
- Variations in plasma amino acid concentrations after abdominal surgical procedures.Acta Chir. Scand. 1974; 140: 271
- Intravenous amino acids solutions.Br. J. Hosp. Med. 1975; 13: 81
- Changes in individual plasma amino acids following experimentally induced and fly fever virus infection.Metabolism. 1972; 21: 67
Article info
Publication history
Accepted:
April 14,
1976
Identification
Copyright
© 1977 Published by Elsevier Inc.
