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Abstract
Allopurinol, Collins' solution, and spermidine were tested for their ability to preserve
nuclear function during kidney storage. Spermidine increased nuclear ribonucleic acid
(RNA) polymerase activity 25 to 43 percent after 60 minutes of warm ischemia. Collins'
solution was less effective and allopurinol did not protect RNA polymerase activity.
Spermidine offered little additional protection over Collins' during cold storage
of RNA polymerase activity. Only spermidine prevented the decrease in the molecular
weight of RNA transcribed following kidney storage. Only Collins' solution prevented
the breakdown of rapidly labeled heterogenous high molecular weight RNA and ribosomal
precursor RNA.
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Article info
Publication history
Accepted:
May 11,
1976
Footnotes
☆Supported by the Veterans Administration Basic Institutional Support, Project No. 5176-01 and United States Public Health Service Grant No. 16184-04.
Identification
Copyright
© 1977 Published by Elsevier Inc.
