Advertisement
Surgery
Advanced searchSave search
Original communication| Volume 81, ISSUE 3, P345-350, March 1977

A new in vivo assay of human lymphocyte-mediated immunity to melanoma

  • Raymond E. Richmond
    Footnotes
    Affiliations
    From the Division of Oncology, Department of Surgery, University of California at Los Angeles School of Medicine, University of California, Los Angeles, Calif., USA

    From the Surgical Services, Sepulveda Veterans Administration Hospital, Sepulveda, Calif. USA
    Search for articles by this author
  • Courtney M. Townsend Jr.
    Footnotes
    Affiliations
    From the Division of Oncology, Department of Surgery, University of California at Los Angeles School of Medicine, University of California, Los Angeles, Calif., USA

    From the Surgical Services, Sepulveda Veterans Administration Hospital, Sepulveda, Calif. USA
    Search for articles by this author
  • Donald L. Morton
    Correspondence
    Reprint requests: Donald L. Morton, M.D., Division of Oncology, Department of Surgery, UCLA School of Medicine, The Center for Health Sciences, Los Angeles, Calif. 90024.
    Affiliations
    From the Division of Oncology, Department of Surgery, University of California at Los Angeles School of Medicine, University of California, Los Angeles, Calif., USA

    From the Surgical Services, Sepulveda Veterans Administration Hospital, Sepulveda, Calif. USA
    Search for articles by this author
  • Author Footnotes
    1 Raymond E. Richmond is a recipient of a National Institute of Health fellowship, No. CA05301-01, and Courtney M. Townsend, Jr. is the recipient of a National Institute of Health fellowship, No. CA00843-01.
DOI:https://doi.org/10.5555/uri:pii:0039606077902410
A new in vivo assay of human lymphocyte-mediated immunity to melanoma
Previous ArticleReconstruction of the cervical esophagus by transplantation and revascularization of a small intestinal segment: Ten year follow-up
Next ArticleHarvey Cushing: “From tallow dip to television”
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Lymphocytes from melanoma patients more frequently inhibited the growth of human melanoma cells in the hamster cheek pouch than did lymphocytes from normal donors. Growth inhibition was accomplished with a much lower ratio of target cells to lymphocytes than in in vitro assays. The hamster cheek pouch assay can be used to study the relationship of blocking factors and humoral antibodies to cell-mediated immunity against human cancers.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Adams R.A.
        • Pothier L.
        • Hellerstein E.E.
        • et al.
        Malignant immunoblastoma: Immunoglobulin synthesis and the progression to leukemia in heterotransplanted acute lymphoblastic leukemia, chronic lymphatic leukemia, lymphoma, and infectious mononucleosis.
        Cancer. 1973; 31: 1397
        • Goldenberg D.M.
        • Bhan R.D.
        • Pavia R.A.
        Retention of human properties by a xenografted human tumor, GW-77, propagated in unconditioned hamsters.
        in: Proc. Soc. Exp. Biol. Med. 135. 1970: 657
        • Golub S.H.
        • Sulit H.L.
        • Morton D.L.
        The use of viable frozen lymphocytes for studies in human tumor immunology.
        Transplantation. 1975; 19: 195
        • Haley H.B.
        • Stroud A.N.
        Constancy of chromosome karyotype in human tumors, H. Ad. #1 and H. Ep. #3 maintained by laboratory animals.
        Cancer Res. 1964; 24: 639
        • Hellstrom I.
        A colony inhibition (CI) technique for demonstration of tumor cell destruction by lymphoid cells in vitro.
        Int. J. Cancer. 1967; 2: 65
        • Hellstrom K.E.
        • Hellstrom I.
        Lymphocyte-mediated cytotoxicity and blocking serum activity to tumor antigens.
        Adv. Immunol. 1974; 18: 209
        • Klein G.
        • Sjogren H.O.
        • Klein E.
        • et al.
        Demonstration of resistance against methylcholanthrene-induced sarcomas in the primary autochthonous host.
        Cancer Res. 1960; 20: 1561
        • Old L.J.
        • Boyse E.A.
        Immunology of experimental tumors.
        Ann. Rev. Med. 1964; 15: 167
        • O'Toole C.
        • Unsgaard B.
        • Almgard L.E.
        • et al.
        The cellular immune response to carcinoma of the urinary bladder: Correlation to clinical stage and treatment.
        Br. J. Cancer. 1973; 28: 266
        • Perlman P.
        Lymphocyte cytotoxicity: Technical aspects. Introduction.
        Transplant. Proc. 1972; 4: 295
        • Richmond R.E.
        Growth characteristics of human melanoma xenografts in hamster cheek pouch.
        in: Proc. Am. Assoc. Cancer Res. 15. 1974: 138
        • Richmond R.E.
        • Morton D.L.
        A hamster cheek pouch assay of human cell-mediated immunity to human melanoma xenografts escaping immunosurveillance by human lymphocytes.
        in: Proc. Am. Assoc. Cancer Res. 16. 1975: 146
        • Rosenau W.
        • Morton D.L.
        Tumor-specific inhibition of growth of methylcholanthrene-induced sarcomas in vivo and in vitro by sensitized isologous lymphoid cells.
        J. Nat. Cancer Inst. 1966; 36: 825
        • Southam C.M.
        • Brunschwig A.
        • Levin A.G.
        • et al.
        Effect of leukocytes on transplantability of human cancer.
        Cancer. 1966; 19: 1743
        • Takasugi M.
        • Mickey M.R.
        • Terasaki P.I.
        Reactivity of lymphocytes from normal persons on cultured tumor cells.
        Cancer Res. 1973; 33: 2898
        • Winn H.J.
        The immune response and the homograft reaction.
        J. Nat. Cancer Inst. 1960; 2: 113

      Article info

      Publication history

      Accepted: May 11, 1976

      Footnotes

      ☆These investigations were supported by United States Public Health Service grants CA12582, CA05262, NIH 073200 CB43852, CA55442, Medical Research Service of the Veterans Administration and the California Institute for Cancer Research.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606077902410

      Copyright

      © 1977 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect
      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties. The content on this site is intended for healthcare professionals.


      RELX