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Abstract
In five awake mongrel dogs, endogenous gastrin was released by continuous irrigation
of the antrum with acetylcholine. After 60 minutes of antral perfusion, the entire
vascular supply of the antrum was suddenly and totally occluded, and serial samples
of peripheral blood were taken for measurement of gastrin. The rate of disappearance
of endogenous gastrin was calculated by standard linear regression analysis; the calculated
half-life of endogenous gastrin was 8.62 minutes. Analysis of the data suggests that
the disappearance rate of endogenous gastrin could be explained by two distinct half-lives:
one of 2.8 minutes (which is similar to the half-time in dogs of both 14- and 17-amino
acid gastrin), and another of 15.4 minutes (which is similar to the half-time of 34-amino
acid gastrin). Physiologically released gastrin is a mixture of three or more molecular
forms of gastrin and the half-life of 8.62 minutes probably represents the disappearance
half-time of this mixture.
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Article info
Publication history
Accepted:
May 19,
1976
Footnotes
☆Supported by a grant from the National Institutes of Health (AM 15241).
Identification
Copyright
© 1977 Published by Elsevier Inc.
