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Abstract
Forty-five patients with varying biliary pathology were injected with one gram of
intramuscular cefazolin sodium prior to surgery. Serum, gallbladder bile, and common
duct bile levels were measured. The type of biliary disease did not influence serum
levels (mean, 29 μg per milliliter) which reached a peak one hour after injection.
Mean common duct bile levels were reduced from 52 μg per milliliter in nonjaundiced
patients to 4 μg per milliliter in those with jaundice (p < 0.001). Patients with
radiologically functioning gallbladders had significantly higher mean gallbladder
bile levels (21 μg per milliliter; p < 0.005). Surprisingly, the mean gallbladder
bile level in acute cholecystitis was 25 μg per milliliter. As the minimum inhibitory
concentration of cefazolin for organisms commonly found in the bile is 0.5 to 6 μg
per milliliter, we suggest that cefazolin sodium may be of value in the treatment
of biliary disease, particularly acute cholecystitis.
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References
- Concentration of selected intravenously administered antibiotics in experimental surgical wounds.J. Trauma. 1973; 13: 423
- Rifamide in acute cholecystitis and biliary surgery.Br. Med. J. 1971; 3: 284
- The biliary excretion of cefazolin.J. Infect. Dis. 1975; 131: 625
- Serum, tissue and wound levels of two cefalosporins.Br. J. Surg. 1975; 62: 159
- The bacteriology of the obstructed biliary tree.Ann. R. Coll. Surg. Engl. 1973; 52: 316
- Bacteriology and antibiotic selection in biliary tract surgery.Arch. Surg. 1968; 97: 533
- Cefazolin, a new semi synthetic cefalosporin antibiotic. III. Absorption, excretion and tissue distribution in parenteral administration.J. Antibiot. (Tokyo). 1970; 23: 184
- Acute cholecystitis.Br. J. Surg. 1975; 62: 697
- Levels of cefazolin in human bile.J. Infect. Dis. 1973; 128 (Suppl.): S361
- Evaluation of cefazolin, a new cefalosporin antibiotic.Antimicrob. Agents Chemother. 1973; 3: 488
- Cefalexin levels in human bile in presence of biliary tract disease.Br. Med. J. 1972; 3: 441
- Clinical studies in cefazolin in the surgical field.Antimicrob. Agents Chemother. 1970; 10: 467
- Biological properties of three 3-heterocyclic-thiomethyl cefalosporin antibiotics.Antimicrob. Agents Chemother. 1972; 1: 221
Article info
Publication history
Accepted:
June 1,
1976
Footnotes
☆Supported in part by a Wellcome Trust Research Fellowship.
Identification
Copyright
© 1977 Published by Elsevier Inc.
