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Original communication| Volume 81, ISSUE 4, P431-435, April 1977

Morphologic aspects of experimental esophageal lye strictures. II. Effect of steroid hormones, bougienage, and induced lathyrism on acute lye burns

  • Cooley Butler
    Correspondence
    Reprint requests: Cooley Butler, M.D., Department of Pathology, University of Arizona College of Medicine Tucson, Ariz. 85724.
    Affiliations
    From the Departments of Pathology and Surgery, University of Arizona College of Medicine Tucson, Ariz., USA

    From the Tucson Veterans Administration Hospital, Tucson, Ariz., USA
    Search for articles by this author
  • John W. Madden
    Affiliations
    From the Departments of Pathology and Surgery, University of Arizona College of Medicine Tucson, Ariz., USA

    From the Tucson Veterans Administration Hospital, Tucson, Ariz., USA
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  • William M. Davis
    Affiliations
    From the Departments of Pathology and Surgery, University of Arizona College of Medicine Tucson, Ariz., USA

    From the Tucson Veterans Administration Hospital, Tucson, Ariz., USA
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  • Erle E. Peacock Jr.
    Affiliations
    From the Departments of Pathology and Surgery, University of Arizona College of Medicine Tucson, Ariz., USA

    From the Tucson Veterans Administration Hospital, Tucson, Ariz., USA
    Search for articles by this author
DOI:https://doi.org/10.5555/uri:pii:0039606077902884
Morphologic aspects of experimental esophageal lye strictures. II. Effect of steroid hormones, bougienage, and induced lathyrism on acute lye burns
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      Abstract

      Among 77 dogs surviving standardized transmural esophageal lye injury for at least 2 weeks and as long as 12 weeks, 24 were untreated, 26 received corticosteroids and bougienage (S&B), and 27 received only the lathyrogen beta-aminoproprionitrile (BAPN). Stricture frequency was reduced markedly and significantly in the S&B and BAPN groups when compared to the controls (p < 0.01). Strictures resulted from inward circumferential remodeling of all mural layers, not proliferating bulky scar tissue, and persistent ulceration was apparently not an influential factor in any group. The S&B dogs invariably showed reduction of the internal or mucosal length of the injured segment as compared to the outer length; these relations were quite variable in the other two groups so that mean internal shortening was significantly greater (p < 0.01) in the S&B group. Marked mural thinning in the injured zone was present in all three groups but was most frequent in the BAPN-treated animals. The major conclusion is that BAPN-induced changes in the physical properties of reparative tissue can increase the ultimate caliber of an injured hollow viscus without resort to mechanical bougienage. In addition, the data suggest that wound contraction may play a role in stricture formation in this model.
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      Article info

      Publication history

      Accepted: June 10, 1976

      Footnotes

      ☆Supported by Grant AM 14047, National Institutes of Arthritis, Metabolic, and Digestive Diseases, National Institutes of Health, Bethesda, Md.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606077902884

      Copyright

      © 1977 Published by Elsevier Inc.

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