Advertisement
Surgery
Advanced searchSave search
Original communication| Volume 81, ISSUE 4, P462-468, April 1977

Download started.

Ok

Physiologic observations of the heart six months after ischemic normothermic cardioplegia

DOI:https://doi.org/10.5555/uri:pii:003960607790294X
Physiologic observations of the heart six months after ischemic normothermic cardioplegia
Previous ArticleBlood flow measurements in arteriovenous dialysis fistulas
Next ArticleIdentification of the presence and type of biliary microflora by immediate gram stains
      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      The late effects of normothermic ischemic cardioplegia were studied in four experimental groups of dogs subjected to intervals of aortic cross-clamping during cardiopulmonary bypass. Groups which had zero, 20, 30, or 40 minutes of aortic cross-clamping, respectively, were studied 6 months later for cardiac performance and morphology. The immediate operative mortality rate of animals subjected to 40 minutes of ischemia was 65 percent, compared to 22 percent in controls. There were no late deaths in any group Compliance, histology, biochemical determination of deoxyribonucleic acid: ribonucleic acid, and Vmaxdeterminations after cross-clamping revealed no differences between the experimental groups. Open chest isovolumetric contraction curves showed decreased function in the 40 minute ischemia group at the extreme levels of cardiac stress. These results suggest that under the conditions of this study normothermic cardiac ischemia of greater than 30 minutes in duration results in a high initial mortality rate (65 percent) and leads to compromise of cardiac function under stress in the late postoperative period.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Register: Create an account
      Institutional Access: Sign in to ScienceDirect

      References

        • Ashwell G.
        Colorimetric analysis of sugars.
        in: Methods in enzymology. Vol. III. Academic Press Inc, New York1957
        • Benzing III, G.
        • Stochert J.
        • Nave E.
        • et al.
        Intermittent myocardial ischemia during cardiopulmonary bypass.
        J. Thorac. Cardiovasc. Surg. 1973; 65: 108
        • Bernheim F.
        • Bernheim M.L.C.
        The effect of various conditions of the respiration of rat heart muscle in vitro.
        Am. J. Physiol. 1944; 141: 195
        • Blumgart H.L.
        • Gilligan D.R.
        • Schlesinger M.J.
        Experimental studies of the effect of temporary occlusion of coronary arteries. II. The production of myocardial infarction.
        Am. Heart. J. 1941; 22: 374
        • Bolooki H.
        • Rooks J.J.
        • Viera C.E.
        • et al.
        Comparison of the effect of temporary or permanent myocardial ischemia on cardiac function and pathology.
        J. Thorac. Cardiovasc. Surg. 1968; 56: 590
        • Buja L.M.
        • Levitsky S.
        • Ferrans V.J.
        • et al.
        Acute and chronic effects of normothermic anoxia of canine hearts: Light and electron microscopic evaluation.
        Circulation. 1971; 43: 44
        • Burdette W.J.
        • Ashford T.P.
        Structural changes in the human myocardium following hypoxia.
        J. Thorac. Cardiovasc. Surg. 1965; 50: 210
        • Ebert P.A.
        • Greenfield L.J.
        • Austen W.G.
        • et al.
        Experimental comparison of methods for protecting the heart during aortic occlusion.
        Ann. Surg. 1962; 155: 25
        • Enright L.P.
        • Staroscik R.N.
        • Reis R.L.
        Left ventricular function after occlusion of the ascending aorta. Assessments of various methods for myocardial protection.
        J. Thorac. Cardiovasc. Surg. 1970; 60: 737
        • Greenberg J.J.
        • Edmunds Jr., L.H.
        Effect of myocardial ischemia at varying temperatures on left ventricular function and tissue oxygen tension.
        J. Thorac. Cardiovasc. Surg. 1961; 42: 84
        • Jennings R.B.
        • Sommers H.M.
        • Herdson R.B.
        • et al.
        Ischemic injury of myocardium.
        Ann. N. Y. Acad. Sci. 1969; 156: 61
        • Kardesch M.
        • Hogancamp C.E.
        • Bing R.J.
        The effect of complete ischemia on the intracellular electrical activity of the whole mammalian heart.
        Circ. Res. 1958; 6: 715
        • Levitsky S.
        • Sloane R.E.
        • Mullin E.M.
        • et al.
        Normothermic myocardial anoxia. Effects on the canine heart with left ventricular outflow obstruction.
        Ann. Thorac. Surg. 1971; 11: 229
        • Mason D.T.
        Usefulness and limitations of the rate of rise of intraventricular pressure (Math Eq) in the evaluation of myocardial contractility in man.
        Am. J. Cardiol. 1969; 23: 516
        • Mason D.T.
        • Braunwald E.
        • Covell J.W.
        • et al.
        Assessment of cardiac contractility. The relation between the rate of pressure rise and ventricular pressure during isovolumic systole.
        Circulation. 1971; 44: 47
        • Mason D.T.
        • Spann Jr., J.F.
        • Zelis R.
        Quantification of the contractile state of the intact human heart. Maximal velocity of contractile element shortening determined by the instantaneous relation between the rate of pressure rise and pressure in the left ventricle during isovolumic systole.
        Am. J. Cardiol. 1970; 26: 248
        • Mejbaun W.
        Uber die Bestimmung Kleiner Pentosemengen, Insbesondere in Derivation der Adenylsaure.
        Hoppe Seylers. Ze. Physiol. Chem. 1939; 258: 117
        • Partin J.S.
        • Benzing III, G.
        • Partin J.C.
        Quantitative fine structural changes in dog heart following cardiopulmonary bypass.
        J. Mol. Cell. Cardiol. 1972; 4: 345
        • Partin J.S.
        • Partin J.C.
        • Benzing III, G.
        Early mitochondrial alterations in dog hearts following three periods of total aortic occlusion of cardiopulmonary bypass.
        in: Proc. Electron Microscope Soc, Boston, 1971 Claiton Book Publishing Division, Baton Rouge, La1971: 290 (published in)
        • Sonnenblick E.H.
        • Gorlin R.
        Reversible and irreversible depression of ischemic myocardium.
        N. Engl. J. Med. 1972; 286: 1154
        • Stoney R.J.
        • Roe B.B.
        Ventricular function after induced, intermittently ischemic ventricular fibrillation: Effect of moderate hypothermia.
        J. Thorac. Cardiovasc. Surg. 1964; 48: 838
        • Webb J.L.
        • Saunders P.R.
        • Thienes C.H.
        The metabolism of the heart in relation to drug action. I. The endogenous aerobic metabolism of rat heart slices.
        Arch. Biochem. 1949; 22: 444
        • Weirich W.L.
        • Jones R.W.
        • Burke M.F.
        The effects of elective cardiac arrest induced by potassium citrate and acetylcholine on ventricular function.
        in: Surg. Forum. 10. 1959: 528
        • Wolk M.J.
        • Keefe J.F.
        • Bing O.H.L.
        • et al.
        Estimation of Vmax in auxotonic systoles from the rate of relative increase of isovolumic pressure (Math Eq) kp.
        J. Clin. Invest. 1971; 50: 1276

      Article info

      Publication history

      Accepted: June 22, 1976

      Identification

      DOI: https://doi.org/10.5555/uri:pii:003960607790294X

      Copyright

      © 1977 Published by Elsevier Inc.

      ScienceDirect

      Access this article on ScienceDirect

      The content on this site is intended for healthcare professionals.


      We use cookies to help provide and enhance our service and tailor content. To update your cookie settings, please visit the Cookie Preference Center for this site.
      Copyright © 2023 Elsevier Inc. except certain content provided by third parties.


      RELX