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Abstract
Three young family members with recurrent arterial thrombosis underwent investigation
for lipid or coagulation abnormalities. Lipoprotein electrophoresis, cholesterol,
triglyceride levels, and routine coagulation studies were unremarkable. By contrast,
testing of platelet function showed enhanced platelet aggregability to epinephrine
and collagen in two of the subjects. In addition, release of 14C-serotonin by adenosine diphosphate and epinephrine was increased over control values
in these same two patients. The third subject demonstrated decreased platelet aggregation
and lowered 14C-serotonin release, but was symptomatic with rest pain at the time of testing. The
ongoing in vivo thrombosis in the third subject may account for hypocoagulable platelets
by in vitro testing. These abnormally sensitive platelets identified by platelet function
testing may be associated with a familial “hypercoagulability” syndrome. Definition
of the hemostatic abnormality in these individuals provided a rational basis for pharmacological
therapy with antiplatelet drugs, which appeared to be successful.
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Article info
Publication history
Accepted:
March 31,
1977
Footnotes
☆Supported in part by a grant (4218827) from the National Institutes of Health, Bethesda, Md.
☆☆Presented in part at the Surgical Forum, American College of Surgeons, Miami, Fla., October, 1974.
Identification
Copyright
© 1978 Published by Elsevier Inc.
