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Original communication| Volume 83, ISSUE 2, P194-199, February 1978

Role of the sympathetic nervous system in peptic ulcer production in rats

DOI:https://doi.org/10.5555/uri:pii:0039606078902787
Role of the sympathetic nervous system in peptic ulcer production in rats
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      Abstract

      The role of the sympathetic nervous system in gastric acid secretion and in experimental duodenal ulceration (cysteamine induced) was studied in rats. The animals were divided randomly into seven groups: (1) control, (2) sham-operated, (3) surgical sympathectomy, (4) chemical sympathectomy (6-HODA), (5) vagotomy, (6) surgical sympathectomy plus vagotomy, and (7) chemical sympathectomy plus vagotomy. Results on gastric acid secretion were expressed as gastric acid output (GAO = μEq of acid secretion in 1 hour). The means in the control and sham groups were 447.83 ± 26.67 GAO and 399 ± 36.4 GAO, respectively. The means in the sympathectomized rats (surgically = 562 ± 27.21 GAO and chemically = 648.66 ± 46.53 GAO) were higher (P < 0.01) than those of the control and sham groups. In the vagotomized group the mean was 156.6 ± 17.64 GAO, lower than those of the control and sham groups (P < 0.001). The incidence of ulceration was 47.5% and 46% in the control and sham groups, respectively. Both the sympathectomized groups (surgically, 73%; chemically, 77%), had a significantly elevated incidence of ulceration as compared with the controls (P < 0.01). The vagotomized group had a 14% incidence of ulceration. These results clearly indicate that sympathectomy has a definite effect on gastric acid secretion and on the incidence of experimental peptic ulceration in rats.
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      Article info

      Publication history

      Accepted: April 12, 1977

      Footnotes

      ☆Supported by funds from the Ray and Joan Kroc Endowment Fund, the Veterans Administration West Side Hospital, Chicago, Ill., and the Taylorville United Way Campaign.

      Identification

      DOI: https://doi.org/10.5555/uri:pii:0039606078902787

      Copyright

      © 1978 Published by Elsevier Inc.

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