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Abstract
Selective thromboxane inhibitors were evaluated as a pharmacological agent in the
prevention of progressive dermal ischemia after burning. Standarized partial-thickness
burns were inflicted on guinea pigs. Burned guinea pigs were separated into four groups:
one served as a control, one was treated with Imidazole, one with dipyridamole, and
the other with methimazole. Histology and depth of dermal perfusion were evaluated
by the India ink perfusion technique. Untreated controls showed progressive dermal
ischemia with complete absence of India ink-filled vessels in the dermis by 24 hours.
Imidazole, dipyridamole, and methimazole improved dermal perfusion as suggested by
relative levels of India Ink filling. Preservation of dermal appendages was seen seondarily
to improved dermal microcirculation with an eight-fold increase in hair follicles
in treated guinea pigs compared with controls. This study suggest that thromboxane
plays a role in progressive dermal ischemia. Selective inhibition of thromboxane avoids
the side effects associated with complete suppression of the metabolism of arachidonic
acid.
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Article info
Publication history
Accepted:
March 28,
1979
Identification
Copyright
© 1980 Published by Elsevier Inc.
