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Selective thromboxane inhibitors were evaluated as a pharmacological agent in the prevention of progressive dermal ischemia after burning. Standarized partial-thickness burns were inflicted on guinea pigs. Burned guinea pigs were separated into four groups: one served as a control, one was treated with Imidazole, one with dipyridamole, and the other with methimazole. Histology and depth of dermal perfusion were evaluated by the India ink perfusion technique. Untreated controls showed progressive dermal ischemia with complete absence of India ink-filled vessels in the dermis by 24 hours. Imidazole, dipyridamole, and methimazole improved dermal perfusion as suggested by relative levels of India Ink filling. Preservation of dermal appendages was seen seondarily to improved dermal microcirculation with an eight-fold increase in hair follicles in treated guinea pigs compared with controls. This study suggest that thromboxane plays a role in progressive dermal ischemia. Selective inhibition of thromboxane avoids the side effects associated with complete suppression of the metabolism of arachidonic acid.
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- Dipyridamole—a possible potent inhibitor of thromboxane A2 synthesis in vascular smooth muscle.Prostaglandins. 1977; 14: 607-609
- Prostaglandins in human burn blister fluid.Acta Physiol Scand. 1973; 87: 270-276
- Effect of indomethacin on the transcapillary leakage of macromolecules and the effect of prostaglandins in the paw lymph following experimental scalding injury.Ups J Med Sci. 1973; 78: 181-188
- Preventing the prostaglandin effect on dermal ischemia in the burn wound.in: ed 3. Surg Forum. 24. 1978: 603-605
- New pathophysiologic mechanism explaining post burn edema.Burns. 1978; 4: 153-157
- Indomethacin and ASA abolish prostaglandins release from the spleen.Nature (London). 1971; 231: 237-239
- Mechanism of steroid action in inflammation.Prostaglandins. 1976; 12: 403-406
- Increased synthesis of prostaglandins in the guinea pig following scalding injury.Acta Physiol Scand. 1973; 87: 240-245
- Isolation and structure of two PG endoperoxids that cause platelet aggregation.in: ed 3. Proc Natl Acad Sci USA. 71. 1975: 345-349
- Prostaglandins as first mediators of stress.Lancet. 1977; 1: 193
- The diagnosis of the depth of burning.Br J Surg. 1953; 40: 588-596
- Biosynthesis and metabolism of PGE2 in human skin.Scand J Clin Lab Invest. 1972; 29: 289-296
- Prostaglandins in burn injury.in: Robinson HJ Prostaglandin synthetase inhibitors. Raven Press, New York1971: 51-58
- Prostaglandins and thromboxanes in burn injuries in man.in: Presented at the Fifth International Congress on Burn Injuries. 1978: 548
- PGE: A potential mediator of the inflammatory response.Ann NY Acad Sci. 1971; 180: 338-350
- Prostaglandin endoperoxide and thromboxane generating systems and their selective inhibition.Prostaglandins. 1976; 12: 323-329
- Unstable metabolites of arachidonic acid.Br Med Bull. 1978; 34: 129-135
- Human arterial and venous tissues generate prostacyclin, a potent inhibitor of platelet aggregation.Lancet. 1977; 1: 18-21
- Application of Imidazole as a selective inhibitor of thromboxane synthetase in human platelets.in: ed 3. Proc Natl Acad Sci USA. 74. 1977: 1716-1720
- Prostaglandins released into human burn blister fluid.in: Presented at Fifth International Congress on Burn Injuries. 1978: 544
- Prevention of dermal ischemia following thermal injury.Arch Surg. 1978; 113: 621-625
- Collagen Synthesis and prostaglandin inhibition in burns.in: ed 3. Surg Forum. 24. 1978: 601-602
- Aspirin selectively inhibits prostaglandin production in platelets.Nature (London). 1971; 231: 235-237
- Prostaglandins and thromboxane.Ann New Biochem. 1978; 47: 997-1029
- Inhibition of prostaglandin synthesis as a mechanism of action for ASA like drugs.Nature (London). 1971; 231: 232-235
- Reversal of capillary stasis and prevention of burns.Ann Surg. 1974; 180: 98-102
Accepted: March 28, 1979
© 1980 Published by Elsevier Inc.