Advertisement
Original communication| Volume 87, ISSUE 2, P147-152, February 1980

Download started.

Ok

Surgical chemotherapy against lymph node metastases: An experimental study

      This paper is only available as a PDF. To read, Please Download here.

      Abstract

      Accompanying surgical resection of the primary tumor is removal of its drainage lymph nodes. However, all of the minute regional lymph nodes cannot be identified and some may be left behind. If a certain anticancer agent in the form of an emulsion is injected topically into the lymph nodes, it may suppress the lymphatic metastases. Domestic rabbits were used as experimental animals, because transplantable V × 2 tumors are available. The vermiform appendix was selected as the transplantation site because of its rich supply of lymph follicles, simulating lymph nodes historically, and because the path of lymph drainage is very simple. The drainage lymph node, which is located at the root of the appendix, was selected for study. The rate of transfer of bleomycin into lymph nodes and of its sustained release from the nodes was extremely enhanced by the use of a sphere-in-oil-type emulsion—more than two times higher than in the use of a W/O emulsion. Although prolongation of survival time did not take place in animals receiving the bleomycin solution topically or intravenously, five of the seven rabbits receiving the local administration of bleomycin as a sphere-in-oil or a water-in-oil emulsion, between which differences were not found in tumor effects, survived with complete reduction of the lymph node metastases.
      To read this article in full you will need to make a payment

      Purchase one-time access:

      Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
      One-time access price info
      • For academic or personal research use, select 'Academic and Personal'
      • For corporate R&D use, select 'Corporate R&D Professionals'

      Subscribe:

      Subscribe to Surgery
      Already a print subscriber? Claim online access
      Already an online subscriber? Sign in
      Institutional Access: Sign in to ScienceDirect

      References

        • Black MM
        • Feeman C
        Prognostic significance of microscopic structure of gastric carcinomas and their regional nodes.
        Cancer (Philadelphia). 1971; 27: 703-711
        • Gilchrist RK
        Surgical management of advanced cancer of the breast.
        Arch Surg. 1950; 61: 913-929
        • Hashida M
        • Muranishi S
        • Sezaki M
        Evaluation of water-in-oil and microsphere-in-oil emulsions as a specific delivery system of 5-Fluorouracil into lymphatics.
        Chem Pharmacol Bull. 1977; 25: 2410-2418
        • Kidd JG
        • Rous P
        A transplantable rabbit carcinoma originating in a virus-induced papilloma and containing the virus in masked or altered form.
        Exp Med. 1940; 71: 813-838
        • Kusama S
        The factors influencing the postoperative free interval of gastric cancer.
        Stomach Intest. 1977; 12: 61-72
        • Takahashi T
        • Mizuno M
        • Mazima S
        • et al.
        Increased concentration of anti-cancer agents in regional lymph nodes by fat emulsion, with special reference to chemotherapy of metastasis.
        Gann. 1973; 64: 345-350
        • Tanigawa N
        Experimental studies on surgical problems concerning lymphatics. II. Lymphatic vascular changes in the development of cancer.
        Arch Jpn Chir. 1978; 47: 575-584
        • Zeidman I
        • Copeland B
        • Warren S
        Experimental studies on the spread of cancer in the lymphatic system. II. Absence of a lymphatic supply in carcinoma.
        Cancer. 1955; 8: 123-127