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Abstract
A suitable concentration of glutaraldehyde for preservation of aortic heterografts
with a valve was investigated from the view points of immunologic, histological, and
hemodynamic studies. A heterograft model was prepared using dogs and raccoon dogs
in such a way that aortas with valves of raccoon dogs were implanted into the descending
aortas of dogs. A pressure study at 2 to 12 months after implantation demonstrated
the following results: there was no pressure gradient between the graft and recipient
aorta in the fresh graft group, there was a slight pressure gradient of 11 ± 3 and
10 ± 3 mm Hg m the 0.05% and 0.15% glutaraldehyde-preserved groups, respectively,
and a marked pressure gradient of 49 ± 2 mm Hg in the 0.3% glutaraldehyde group. Angiography
showed aneurysmal dilatation of implanted grafts in a fresh graft group, no demonstrable
deformity in the 0.05% and 0.15% preserved grafts, and a marked stenosis and shrinkage
of grafts in the 0.3% group. These changes were substantiated from macroscopic and
histological observation. Immunologic analysis of recipient dog sera using techniques
for antiraccoon-dog hemagglutinin, hemolysin, and lymphocytotoxin revealed an obvious
antigen depressant effect of glutaraldehyde, even in cases in which highly diluted
solution (0.0.5%) was used. These findings may lead us to conclude that a low-concentration
solution of glutaraldehyde (0.15%, or less) is the choice for treatment of heterografts.
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References
- Biological factors affecting long-term results of valvular heterografts.J Thorac Cardiovasc Surg. 1969; 58: 467
- Six-year follow-up of glutaraldehyde-preserved heterograft; with particular reference to the treatment of congenital valve malformations.J Thorac Cardiovasc Surg. 1974; 68: 771
- Immunologic studies of untreated and chemically modified bovine carotid arteries.J Surg Res. 1970; 10: 95
- Discussion.in: Clinical experience with a procine aortic valve xenograft for mitral valve replacement. ed 3. Ann Thorac Surg. 18. 1974: 391
- Homograft replacement of the mitral valve.Circulation. 1968; 38: 664
- Clinical and hemodynamic studies in patients with homograft mitral valve replacement.Circulation. 1972; 44: 334
- Mitral valve replacement with the glutaraldehyde-preserved porcine heterograft; clinical, hemodynamic and pathological correlations.J Thorac Cardiovasc Surg. 1974; 67: 885
- Antigenicity of vascular heterografts.J Surg Res. 1973; 15: 81
- Prosthetic replacement of mitral valve.Circulation. 1974; 29: 2
- A comparative study between glutaraldehyde-preserved aortic and pulmonary heterograft valves in the tricuspid position in dogs.J Cardiovasc Surg. 1976; 17: 178
- The glutaraldehyde-treated heterograft valve; some engineering observations.J Thorac Cardiovasc Surg. 1977; 74: 317
Article info
Publication history
Accepted:
April 18,
1979
Identification
Copyright
© 1980 Published by Elsevier Inc.
