This paper is only available as a PDF. To read, Please Download here.
Abstract
We have studied the influences of duodenal acidification on the effects of bombesin
on gastric and pancreatic secretion and on blood levels of gastrin, secretin, and
cholecystokinin (CCK) in six conscious dogs with chronic gastric and pancreatic fistulas.
Duodenal acidification suppressed bombesin-stimulated gastric acid output (from 20.1
± 4.2 to 8.2 ± 1.9 mEq/120 min) and gastrin release (from an integrated 2-hour output
of 16.0 ± 1.2 to 11.1 ± 1.1 ng-min/ml). On the other hand, duodenal acidification
augmented bombesin-stimulated secretion of pancreatic bicarbonate (from 0.75 ± 0.12
to 7.81 ± 2.0 mEq/120 min) and protein (from 0.57 ± 0.10 to 1.00 ± 0.18 gm/120 min).
Blood levels of CCK (but not of secretin) were increased with bombesin alone, whereas
blood levels of secretin (but not CCK) were increased by duodenal acidification alone.
Bombesin plus duodenal acidification resulted in increase of both CCK and secretin.
This increase of secretin may be responsible, in part, for suppression of both gastric
acid output and gastrin release, as well as for increases in pancreatic secretion
of bicarbonate and protein.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- External pancreatic secretion after bombesin infusion in man.Gut. 1975; 16: 994-998
- Effects of secretin, glucagon and duodenal acidification on bombesin-induced hypergastrinemia in man.Am J Gastroenterol. 1976; 66: 448-451
- Gastrin release by bombesin in the dog.Br J Pharmacol. 1974; 52: 219-225
- Actions of bombesin on secretions and motility of the gastrointestinal tract.in: Thompson JC Gastrointestinal hormones. University of Texas Press, Austin1974: 575-589
- Evidence of cholecystokinin release by bombesin in the dog.Br J Pharmacol. 1974; 52: 227-232
- Effect of bombesin on serum gastrin and cholecystokinin in dogs.in: ed 3. Surg Forum. 27. 1976: 414-416
- A new cannula for the study of pancreatic function.J Appl Physiol. 1968; 25: 207-209
- Dynamic characteristics of gastrin release.Am J Surg. 1972; 123: 137-142
- Effect of bombesin and related peptides on the release and action of intestinal hormones on pancreatic secretion.J Physiol. 1976; 257: 663-672
- Estimation of protein by the folin-ciocalten reaction.in: ed 3. Methods in immunology and immunochemistry. vol II. Academic Press, Inc, New York1968: 273
- Influence of duodenal acidification on the secretory and hormonal-release effects of bombesin.Scand J Gastroenterol. 1978; A13: 123
- Plasma levels of secretin in man and dogs: validation of a secretin radioimmunoassay.Surgery. 1976; 79: 658-665
- Effect of duodenal fat on plasma levels of gastrin and secretin and on gastric acid responses to gastric and intestinal meals in dogs.Gastroenterology. 1978; 75: 773-777
- Radioimmunoassay of secretin.in: Grossman M Speranza V Basso N Lezoche E Gastrointestinal hormones and pathology of the digestive system. Plenum Publishing Corp, New York1978: 309-316
- Cholecystokinin radioimmunoassay.in: Bloom SR Gut hormones. Churchill-Livingstone, Ltd, Edinburgh1978: 208-212
- Comparison of serum levels of gastrin and cholecystokinin in dogs measured by radioimmunoassay.Scand J Gastroenterol. 1978; 13: 151
- Measurement of endogenous release of cholecystokinin by radioimmunoassay.Ann Surg. 1973; 178: 304-310
- Statistical aspects of radioimmunoassays.in: Odell WD Daughaday WH Principles of competitive protein binding assays. JB Lippincott Co, Philadelphia1971: 204-259
- Physiologic release of secretin measured in peripheral and portal venous blood.Digestion. 1978; 17: 509-515
- Effect of secretin on circulating gastrin.Ann Surg. 1972; 176: 384-393
- Cholecystokinin metabolism in man and dogs.Ann Surg. 1975; 182: 496-504
- A method for producing specific antisera with small doses of immunogen.J Clin Endocrinol Metab. 1971; 33: 988-995
- Radioimmunoassay methodology for articles published in Gastroenterology.Gastroenterology. 1978; 75: 523-524
Article info
Publication history
Accepted:
May 22,
1979
Footnotes
☆Supported by grants from the National Institutes of Health (AM 15241), Bethesda, Md., the John A. Hartford Foundation, Inc., and the Research and Development Fund of the Department of Surgery, The University of Texas Medical Branch, Galveston, Texas.
☆☆Presented in part at the Second International Symposium on Gastrointestinal Hormones, Beito, Norway, Aug. 31–Sept. 3, 1978. A preliminary abstract of that presentation has appeared.11
Identification
Copyright
© 1980 Published by Elsevier Inc.
