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Abstract
The hemodynamic and histologic effects of exogenous prostacyclin (PGI2) and prostaglandin E1 (PGE1) on oleic acid-induced acute respiratory failure were investigated. Adult mongrel
dogs infused with oleic acid were treated with saline solution, PGE1, and PGI2. Significantly lowered blood pressure, systemic and pulmonary vascular resistance,
and arteriovenous oxygen difference and preservation of preoleic cardiac output were
observed in the PGI2 group. Compared with the saline group, only the arteriovenous oxygen difference was
improved with PGE1. Light microscopy revealed acute edema and inflammation in the saline- and PGE1-treated lungs. Histologic specimens in the PGI2 group were normal.
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Article info
Publication history
Accepted:
March 17,
1982
Footnotes
☆Supported by CMDNJ/New Jersey Medical School Foundation grant 625027 and NIH grants 13143-09 and 25831-03.
Identification
Copyright
© 1982 Published by Elsevier Inc.
