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Abstract
The hepatic uptake of unlabeled synthetic human gastrin I (1–17) was determined in
four unanesthetized patients who did not have hepatic or gastroduodenal disease. The
hormone was given by brief infusion and at rates producing concentrations of immunoreactive
gastrin within the physiologic range. We estimated the first-pass fractional hepatic
uptake by comparing the results after a portal and a peripheral infusion in each patient.
It was −0.01 ± 0.14 (mean ± SD), demonstrating lack of hepatic uptake of gastrin I
(1–17) in humans.
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Article info
Publication history
Accepted:
July 21,
1982
Identification
Copyright
© 1983 Published by Elsevier Inc.
