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Abstract
The technique of γ-imaging can be used to study the deposition of 111In-labeled platelets onto synthetic arterial grafts in vivo. Recent results suggested
that platelet uptake on polytetrafluoroethylene (PTFE) grafts might depend on the
choice of anesthetic. To evaluate the effect of anesthesia a series of experiments
was performed in seven dogs wherein each animal served as its own control. The first
of paired femoral or carotid PTFE grafts was inserted with the animal under pentobarbital
anesthesia, and the graft was imaged for 90 minutes. A second graft was then inserted
after at least 1 hour of halothane anesthesia. The mean activity ratio (describing
platelet deposition) in the grafts inserted when only pentobarbital anesthesia was
used was 7.04 ± 0.55, compared to 1.20 ± 0.07 in the grafts inserted with halothane
anesthesia (P < 0.01). Halothane anesthesia led to significantly decreased platelet
uptake on canine PTFE arterial grafts. This effect was reversible, though not immediately,
with no significant difference in graft activity noted by the day following surgery.
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References
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Article info
Publication history
Accepted:
September 1,
1982
Footnotes
☆Supported by grant HL23762 from the U.S. Public Health Service and by a Research Fellowship from the American Heart Association, Greater Boston Division.
Identification
Copyright
© 1983 Published by Elsevier Inc.
