This paper is only available as a PDF. To read, Please Download here.
Two hundred seventy-four diabetic patients were studied over a 2-year period to evaluate the progression of lower extremity atherosclerotic occlusive disease (ASO). At initial evaluation, ASO was noted in 98 patients (36%). Incidence of new or more severe disease was noted in 92 patients (34%) at follow-up. Increased age, longer duration of diabetes, lower percent ideal body weight, elevated systolic blood pressure, and elevated serum cholesterol levels were all significantly associated with disease progression. Patients with disease progression were found to have significantly lower nerve motor velocities and sensory conduction, higher serum creatinine levels, and a higher prevalence of retinopathy, proteinuria, and carotid artery disease (perhaps indicating concomitant neuropathy and microvascular disease). Diastolic pressure, race, fasting and postprandial glucose, fasting and postprandial insulin, fasting and postprandial C peptides, and glycosylated hemoglobin levels did not correlate with disease progression. The strongest prognostic indicator of disease progression appeared to be preexisting disease. Significant disease progression over a relatively short period indicates that treatment of the diabetic patients who have symptoms should be early and aggressive.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Lower extremity amputation in diabetic patients.Diabetes. 1970; 19: 189-195
- Morbidity and mortality in diabetics in the Framingham population: Sixteen year follow up.Diabetes. 1974; 23: 105-111
- Chicago1979 Peripheral vascular disease in diabetics. Presented at the Third Annual Meeting of the Midwestern Vascular Surgical Society,
- Peripheral vascular disease in diabetes mellitus and its relation to cardiovascular risk factors: Screening with the Doppler ultrasonic technique.Diabetes Care. 1980; 3: 207-213
- Diabetes, hyperglycemia and atherosclerosis: New research directions.in: Diabetes mellitus. DHEW publication NIH Washington, DC. US Government Printing Office, 1976: 194-212 (76-854)
- Diabetes mellitus and arteriosclerosis.in: Schettler FG Atherosclerosis. Elsevier/North Holland Biomedical Press, New York1969
- Epidemiology of diabetes and its vascular lesions.Elsevier/North Holland Biomedical Press, New York1978
☆Presented at the Sixth Annual Meeting of the Midwestern Vascular Surgical Society, Milwaukee, Wis., Sept. 24–25, 1982.
© 1983 Published by Elsevier Inc.