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Abstract
Two hundred seventy-four diabetic patients were studied over a 2-year period to evaluate
the progression of lower extremity atherosclerotic occlusive disease (ASO). At initial
evaluation, ASO was noted in 98 patients (36%). Incidence of new or more severe disease
was noted in 92 patients (34%) at follow-up. Increased age, longer duration of diabetes,
lower percent ideal body weight, elevated systolic blood pressure, and elevated serum
cholesterol levels were all significantly associated with disease progression. Patients
with disease progression were found to have significantly lower nerve motor velocities
and sensory conduction, higher serum creatinine levels, and a higher prevalence of
retinopathy, proteinuria, and carotid artery disease (perhaps indicating concomitant
neuropathy and microvascular disease). Diastolic pressure, race, fasting and postprandial
glucose, fasting and postprandial insulin, fasting and postprandial C peptides, and
glycosylated hemoglobin levels did not correlate with disease progression. The strongest
prognostic indicator of disease progression appeared to be preexisting disease. Significant
disease progression over a relatively short period indicates that treatment of the
diabetic patients who have symptoms should be early and aggressive.
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References
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Article info
Footnotes
☆Presented at the Sixth Annual Meeting of the Midwestern Vascular Surgical Society, Milwaukee, Wis., Sept. 24–25, 1982.
Identification
Copyright
© 1983 Published by Elsevier Inc.
