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Abstract
A surgical experience with 530 orthotopic liver transplants in rats is reviewed with
technical details. Liver transplantation in the rat can provide important data in
a variety of areas, including immunology. Nevertheless, technical problems have limited
the widespread use of this valuable investigative tool. Cuff techniques for microvascular
anastomosis have simplified the portal venous anastomosis and have minimized the anhepatic
phase in the recipient. These had previously been the most frequent causes of failure
in the utilization of liver transplantation in the rat. The technique for rat liver
transplantation described here was found to be reliable with a 95.3% long-term survival
(longer than 100 days) in a recent group of 85 transplants where rejection was not
a factor. In the early experience, most deaths were due to bleeding, infection, and
biliary complications. The improvements in technique have eliminated most of these
errors. We feel that the use of these technical modifications would increase the success
rate of rat liver transplantation in the hands of others.
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Article info
Publication history
Accepted:
April 8,
1982
Footnotes
☆Supported by M.R.C. Project grants G978/822 and G80/ 0091/8CA and the Daimon-Hagimori Foundation.
Identification
Copyright
© 1983 Published by Elsevier Inc.
