This paper is only available as a PDF. To read, Please Download here.
An artificial esophagus was made of silicone rubber (Phycon) tube covered with a Dacron mesh. A segment of thoracic esophagus of 16 dogs was replaced with this graft using three different types of anastomosis—overlayer end-to-end anastomosis with flanged tube, two-layer end-to-end anastomosis with flanged tube, and monolayer end-to-end anastomosis with no flange tube. Seven of 16 dogs (44%) survived more than 12 months without complications, four of them surviving more than 6 years. In six of seven of the prolonged survivors, extrusion of the graft was recognized in the 3 to 6 months after operation. Esophageal stricture increased slightly up to 6 months after extrusion of the graft, but it did not further advance until sacrifice. In these dogs, mucosal regeneration of the neoesophagus was complete with muscle layers and mucous glands in the submucosa recognized microscopically. Proximal esophagus from the replaced portion was apparently dilatated more than that of the distal portion. There was no definite difference between the anastomotic techniques with regard to complication or prognosis. These results suggest that this artificial esophagus should be considered as a possibility for clinical trials in the future.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Replacement of portion of canine esophagus with composite prosthesis and greater omentum.J Thorac Cardiovasc Surg. 1972; 64: 892-896
- The experimental replacement of portions of the esophagus by a plastic tube.Ann Surg. 1952; 135: 337-343
- Reconstruction of the esophagus with wire mesh prosthesis.Surgery. 1958; 43: 600-605
- An experimental study on artificial esophagus (English abstract).Hirosaki-Igaku. 1976; 28: 342-360
- Esophageal reconstruction with autogenous dermal grafts—An experimental study.Surgery. 1956; 39: 459-469
- Primary reconstruction of cervical esophagus use of the free tracheal graft.Arch Otolaryngol. 1964; 79: 258-268
- Die Rekonstruktion des Oesophagus mit Kunst Stoffen. II. Neubildung eines Speiserohres mittels temporärer Leitschiene.Langenbecks Arch Klin Chir. 1967; 317: 51-63
- Study on the artificial esophagus (English abstract).Jinko-Zoki. 1980; 9: 344-347
- Prosthetic replacement of esophageal segments.J Thorac Cardiovasc Surg. 1968; 56: 674-682
- Esophageal mucosal regeneration following experimental prosthetic replacement of the esophagus.Surgery. 1970; 67: 468-473
- Failure of freeze-dried esophageal grafts.Am J Surg. 1953; 86: 152-153
- Segmental replacement of the thoracic esophagus with a Silastic prosthesis.Am J Surg. 1971; 121: 238-240
Accepted: May 14, 1982
© 1983 Published by Elsevier Inc.