Action of carnosine and β-alanine on wound healing

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      In rats treat-given hydrocortisone to suppress healing, tensile strength of the skin at the site of an incision wound was significantly higher in rats locally treated with carnosine than in untreated animals. Similar effects on the tensile strength of the skin were observed by the administration of β-alanine and histidine, but not of β-alanine alone. Exogenous carnosine was degraded in the body by carnosinase and histidine decarboxylase to yield histamine. Since β-alanine, the other degradation product of carnosine, was found to stimulate the biosynthesis of nucleic acids and collagen, histamine derived from carnosine is considered to have enhanced the process of wound healing by stimulating effusion at the initial stage of inflammation. Thus, the enhancement by carnosine of wound healing may be ascribed to stimulation of early effusion by histamine and of collagen biosynthesis by β-alanine. The wound-healing effects of carnosine were further demonstrated by the observation that carnosine significantly increased granulation suppressed by cortisone, mytomycin C, 5-fluorouracil, and bleomycin.


      Se observó que la fuerza de tensión de la piel en el sitio de una incisión hecha en ratas, que habian recibido hidrocortisona para suprimir la cicatrización, fue significativamente más grande en ratas que habian sido tratadas localmente con carnosina que los animales no tratados. Con la administración de β-alanina e histidina se observaron efectos semejantes sobre la fuerza de tensión. Estos efectos no se observaron si se utilizó β-alanina en forma aislada. La carnosina exógena se degrada en el cuerpo por la carnosinasa y HDC para producir histamina, ya que se ha observado que la β-alanina, que es un producto de degradación de la carnosina, estimula la biosíntesis de ácidos nucléicos y colágeno. Nosotros consideramos que la histamina derivada de la carnosina estimula el proceso de cicatrización produciendo una efusión durante las etapas iniciales de la inflamación. De esta manera, el efecto benéfico que tiene la carnosina sobre la cicatrización, se debe a la producción de un derrame inicial producido por la histamina, y a una biosíntesis de colágeno inducido por β-alanina. Los efectos benéficos de la carnosina sobre la cicatrización, fueron observados también en el aumento de tejido de granulación que habia sido suprimido por la cortisona, MMC, 5-FU y bleomisina.
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