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The effect of decreased caffeine consumption on benign proliferative breast disease: A randomized clinical trial

  • Sharon S. Allen
    Correspondence
    Reprint requests: Sharon S. Allen, M.D., Ph.D., Department of Family Practice and Community Health, University of Minnesota Medical School, 516 Delaware St. SE, Box 381 UMHC, Minneapolis, MN 55455.
    Affiliations
    From the Department of Family Practice and Community Health, Medical School, and the School of Public Health, University of Minnesota, Minneapolis, Minn., USA
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  • Debra G. Froberg
    Affiliations
    From the Department of Family Practice and Community Health, Medical School, and the School of Public Health, University of Minnesota, Minneapolis, Minn., USA
    Search for articles by this author
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      Abstract

      A single-blind, randomized clinical trial of 56 female subjects was conducted to determine whether decreased consumption of caffeine decreases breast pain/tenderness or nodularity in patients with suspected benign proliferative breast disease. The subjects were randomly assigned to one of three groups—a control group (no dietary restrictions), a placebo group (cholesterol-free diet), and an experimental group (caffeine-free diet). At the initial examination, the subjects reported on the presence of breast pain, the degree to which pain affects daily activities, the frequency of pain, the degree of pain associated with breast examinations, and the degree of pain associated with close-fitting clothing. Subjects were then examined and the four quadrants of each breast were rated on a scale of 0 to 3 (0 = normal, fatty tissue, 1 = little seedy bumps or fine nodularity, 2 = discrete nodules or ropy tissue, 3 = confluent areas, hard or soft masses). Subjects in all three groups returned for 2- and 4-month follow-up examinations. Total nodularity scores, degree of pain/tenderness, and compliance with dietary restrictions were analyzed. The data showed that decreased caffeine consumption did not result in a significant reduction of palpable breast nodules or in a lessening of breast pain/tenderness.
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      References

        • Minton JP
        • Foecking MK
        • Webster DJT
        • Matthews RH
        Caffeine, cyclic nucleotides, and breast disease.
        Surgery. 1979; 86: 105
        • Minton JP
        • Abou-Issa H
        • Reiches N
        • Roseman JM
        Clinical and biochemical studies on methylxanthine-related fibrocystic breast disease.
        Surgery. 1981; 90: 299-304
        • Brooks PG
        • Gart S
        • Heldfond AJ
        • Margolin ML
        • Allen AS
        Measuring the effect of caffeine restriction on fibrocystic breast disease.
        J Rep Med. 1981; 26: 279-282
        • Ernster VL
        • Mason L
        • Goodson WH
        • et al.
        Effects of caffeine-free diet on benign breast disease: A randomized trial.
        Surgery. 1982; 91: 263-267
        • Marshall J
        • Graham S
        • Swanson M
        Caffeine consumption and benign breast disease: A case-control comparison.
        Am J Public Health. 1982; 72: 610-612
        • Lawson DH
        • Jick H
        • Rothman KJ
        Coffee and tea consumption and breast disease.
        Surgery. 1981; 90: 801-803
        • Lubin F
        • Ron E
        • Wax Y
        • Black M
        • Funaro M
        • Shitrit A
        A case-control study of caffeine and methylxanthines in benign breast disease.
        JAMA. 1985; 253: 2388-2392
        • Boyle CA
        • Berkowitz GS
        • LiVolsi VA
        • et al.
        Caffeine consumption and fibrocystic breast disease: A case-control epidemiologic study.
        J Natl Cancer Inst. 1984; 72: 1015-1019
        • Odenheimer DJ
        • Zunzunegui MV
        • King MC
        • Shipler CP
        • Friedman GD
        Risk factors for benigh breast disease: A case-control study of discordant twins.
        Am J Epidemiol. 1984; 120: 565-571
        • Graham DM
        Caffeine—Its identity, dietary sources, intake and biological effects.
        Nutr Rev. 1978; 36: 97-102
        • Gilbert RM
        Caffeine consumption.
        in: Spiller GA The methylxanthine beverages and foods: chemistry, consumption, and health effects. Alan R. Liss, New York1984: 185-213
        • Heyden S
        • Muhlbaier LH
        Prospective study of fibrocystic breast disease and caffeine consumption.
        Surgery. 1984; 96: 479-483