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Abstract
A histopathologic review was undertaken of 293 patients with breast cancer treated
by local tumor excision and radical radiotherapy. In a 6-year period, there were 37
local treatment failures with 16 deaths, and an additional 20 patients died without
local recurrence. Pathologic data were available for 272 patients. Multivariate analysis
indicated that the pathologic features in an invasive tumor most predictive for local
recurrence were the combination of a high proportion of intraduct carcinoma with extensive
necrosis (comedocarcinoma). Of 18 patients with these features, nine have had early
local recurrence (a risk of 50% with these features vs 10% in those without), and
four have died (a risk of 22% against 12%). Despite the short follow-up, the results
already appear significant, and the study is ongoing. The importance of comedonecrosis
in the intraduct component as a prognostic indicator in invasive carcinoma of the
breast is not widely recognized and might constitute a relative contraindication to
conservative treatment of the breast.
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Article info
Publication history
Accepted:
March 12,
1988
Identification
Copyright
© 1989 Published by Elsevier Inc.
