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Original communication| Volume 106, ISSUE 1, P6-10, July 1989

Hyperthyroidism and concurrent thyroid malignancies

  • Roman Rieger
    Affiliations
    From the First Surgical Department and the Department of Endocrinology and Nuclear Medicine, Landeskrankenanstalten Salzburg, Austria

    From the Department of Surgery, State University of New York-Health Science Center at Brooklyn, Brooklyn, N.Y., USA
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  • Wolfgang Pimpl
    Correspondence
    Reprint requests: Wolfgang Pimpl, MD, First Surgical Department, Landeskrankenanstalten Salzburg, Müllner Hauptstrasse 48, A-5020 Salzburg, Austria.
    Affiliations
    From the First Surgical Department and the Department of Endocrinology and Nuclear Medicine, Landeskrankenanstalten Salzburg, Austria

    From the Department of Surgery, State University of New York-Health Science Center at Brooklyn, Brooklyn, N.Y., USA
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  • Samuel Money
    Affiliations
    From the First Surgical Department and the Department of Endocrinology and Nuclear Medicine, Landeskrankenanstalten Salzburg, Austria

    From the Department of Surgery, State University of New York-Health Science Center at Brooklyn, Brooklyn, N.Y., USA
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  • Lukas Rettenbacher
    Affiliations
    From the First Surgical Department and the Department of Endocrinology and Nuclear Medicine, Landeskrankenanstalten Salzburg, Austria

    From the Department of Surgery, State University of New York-Health Science Center at Brooklyn, Brooklyn, N.Y., USA
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  • Günther Galvan
    Affiliations
    From the First Surgical Department and the Department of Endocrinology and Nuclear Medicine, Landeskrankenanstalten Salzburg, Austria

    From the Department of Surgery, State University of New York-Health Science Center at Brooklyn, Brooklyn, N.Y., USA
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      Abstract

      In a 17-year period 1848 patients with hyperthyroidism were operated on. Fourteen (0.76%) had a coexisting thyroid malignancy. Preoperative scintiscan and pathologic diagnoses were compared: 10 malignancies were in cold nodules, two were unidentifiable preoperatively due to small size, and two were in hot areas. Five patients had papillary cancer, four follicular, three anaplastic, and two medullary. Patients with uninodular toxic goiter had a low rate of associated malignancy (0.27%, 3/1108). In contrast, patients with multinodular toxic goiter had an incidence of 1.63% (11/676). No patient with Graves' disease (n = 64) had a carcinoma. Extensive use of fine-needle aspiration biopsy enabled preoperative diagnosis in a majority of the cases (9/14, 64%). We conclude that the incidence of coexisting thyroid malignancy and hyperthyroidism is rare in our endemic iodine-deficiency goiter area.
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