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Abstract
In a 17-year period 1848 patients with hyperthyroidism were operated on. Fourteen
(0.76%) had a coexisting thyroid malignancy. Preoperative scintiscan and pathologic
diagnoses were compared: 10 malignancies were in cold nodules, two were unidentifiable
preoperatively due to small size, and two were in hot areas. Five patients had papillary
cancer, four follicular, three anaplastic, and two medullary. Patients with uninodular
toxic goiter had a low rate of associated malignancy (0.27%, 3/1108). In contrast,
patients with multinodular toxic goiter had an incidence of 1.63% (11/676). No patient
with Graves' disease (n = 64) had a carcinoma. Extensive use of fine-needle aspiration
biopsy enabled preoperative diagnosis in a majority of the cases (9/14, 64%). We conclude
that the incidence of coexisting thyroid malignancy and hyperthyroidism is rare in
our endemic iodine-deficiency goiter area.
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Article info
Publication history
Accepted:
December 7,
1988
Identification
Copyright
© 1989 Published by Elsevier Inc.
