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Abstract
Intermittent claudication and limb-threatening ischemia caused by occlusion of large
and medium-sized arteries are rare manifestations of systemic lupus erythematosus.
So far only eight documented cases have been reported, predominantly in young women.
In this report two more patients are described. There is no common opinion concerning
pathophysiologic mechanism, but immunologic endothelial damage and circulating antibodies
to phospholipid probably play a role. The results of medical and surgical treatment
are disappointing, and amputation becomes necessary in more than half of the patients.
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Article info
Publication history
Accepted:
December 2,
1988
Identification
Copyright
© 1989 Published by Elsevier Inc.
