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Abstract
Oxygen microelectrodes were used to measure tumor partial pressure of oxygen (Po2) before and after photodynamic therapy (PDT) in a rat transplantable subcutaneous
chondrosarcoma. Before PDT there was a gradient of Po2 from the superficial layers of the tumor (Po2 = 46 ± 6 mm Hg) toward the center of the tumor (Po2 = 10 ± 1 mm Hg). Mean tumor Po2 (21 ± 2 mm Hg) was significantly reduced to 3 ± 1 mm Hg 1 hour after PDT, and this
reduction in Po2 persisted 4 hours (8 ± 2 mm Hg) and 24 hours (6 ± 1 mm Hg) after PDT. The largest
percentage decrease in Po2 occurred at a depth of only 50 μm into the tumor. Inasmuch as PDT has been shown
to decrease blood flow, our data suggest that PDT actions on blood vessels in the
peripheral areas of the tumor are of major importance for eliciting the tumor hypoxia
that contributes to tumor necrosis after PDT.
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Article info
Publication history
Accepted:
December 1,
1988
Footnotes
☆Supported in part by the Center for Applied Microcirculatory Research.
Identification
Copyright
© 1989 Published by Elsevier Inc.
