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Abstract
A major clinical concern with providing total parenteral nutrition to the tumor-bearing
host is the potential to stimulate tumor growth. This study was performed to determine
the effect of total parenteral nutrition on primary tumor growth and spontaneous pulmonary
metastasis in Lobund rats with subcutaneous prostate adenocarcinoma (PA-III) implants.
Significant acceleration of primary tumor growth and tumor metastasis occurred in
animals receiving parenteral nutrition consisting of amino acids, dextrose, and lipid
or standard enteral nutrition compared to control animals. This study represents the
first report of stimulating tumor metastasis with specific parenteral nutrients and
clearly indicates that both primary tumor growth and tumor metastasis can be altered
by exogenous substrate administration.
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Article info
Publication history
Accepted:
August 20,
1990
Footnotes
☆Supported in part by the American Cancer Society Career Development Award 87-114, a Merit Review Grant from the Veterans Administration, and a Research Grant from Clintec, Inc.
Identification
Copyright
© 1991 Published by Elsevier Inc.
