This paper is only available as a PDF. To read, Please Download here.
We studied the effect of the topical application of the nonsteroidal anti-inflammatory agent, flurbiprofen, on postburn hypermetabolism and systemic lipid peroxidation. Twelve sheep with a 15% total body surface third-degree burn were monitored over a 4-day postburn period. In six sheep, a single application of a 5% flurbiprofen cream was placed on the burn wound on day 3. Data were compared to both burned and nonburned controls (n = 6). All animals were killed on day 4. Oxygen consumption was increased at day 3 by 28% ± 10% over the preburn value in all animals. Flurbiprofen significantly attenuated the increase in oxygen consumption, returning the value essentially to baseline by 12 hours after application. Lung and liver peroxidation, as measured by malondialdehyde, was significantly increased in the burned, nontreated sheep at day 4 from a control value of 45 ± 9 and 110 ± 12 to 60 ± 6 and 310 ± 71 nmol/gm tissue, respectively. In flurbiprofen-treated animals, values were 42 ± 8 and 160 ± 18 nmol/gm at day 4, significantly attenuated from burn alone. Protein-rich burn lymph flow remained fourfold increased in both groups, indicating a persistent increase in burn tissue vascular permeability, not modified by flurbiprofen. Burn wound biopsies revealed bacterial contents of less than 104 organisms/gram tissue in all animals. We conclude that topical flurbiprofen significantly decreases burn wound-induced systemic hypermetabolism and oxidant-induced lipid peroxidation seen at 3 days after burn injury, but does not attenuate the remaining local burn-wound vascular permeability.
To read this article in full you will need to make a payment
Purchase one-time access:Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access
One-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:Subscribe to Surgery
Already a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
- Cathecholamines: mediators of the hypermetabolic response to thermal injury.Ann Surg. 1974; 180: 653-658
- Effect of thermal injury on endotoxin induced lung injury.Surgery. 1983; 92: 289-296
- The national history of major burns with multiple subsystem failure.J Trauma. 1983; 23: 102-108
- Early postburn lipid peroxidation: effect of ibuprofen and allopurinol.Surgery. 1990; 107: 85-93
- Role of xanthine oxidase in thermal injury of skin.Am J Pathol. 1989; 135: 195-201
- Effect of a body burn on endotoxin-induced lipid peroxidation: comparison with physiologic and histologic change.Surgery. 1990; 107: 669-676
- The effect of complete burn wound excision and closure on postburn oxygen consumption.Surgery. 1987; 102: 862-868
- Effect of partial burn wound excision and closure on postburn oxygen consumption.Surgery. 1988; 104: 846-852
- Relationship between lung injury and lung lipid peroxidation caused by recurrent endotoxemia.Am Rev Respir Dis. 1989; 139: 1118-1124
- Lung dysfunction after thermal injury in relation to prostanoid and oxygen radical release.J Appl Physiol. 1986; 61: 103-112
- Both inflammatory and endocrine mediators stimulate host responses to sepsis.Arch Surg. 1986; 121: 179-183
- Topical ibuprofen decreases thromboxane release from endotoxin stimulated burn wound.J Trauma. 1986; 26: 157-162
- Renal syndrome associated with nonsteroidal anti-inflammatory drugs.N Engl J Med. 1984; 310: 563-572
- Topical ibuprofen decreases early postburn edema.Surgery. 1987; 102: 857-861
- The effect of nonsteroidal anti-inflammatory drugs on leukocyte migration in carrageenan induced inflammation.Can J Pharmacol. 1980; 66: 81-86
- Pharmacokinetics of flurbiprofen.Am J Med. 1986; 80: 10-15
- Use of chronic prefemoral lymphatic fistulae for monitoring systemic capillary integrity in unanestherized sheep.J Surg Res. 1981; 31: 136-141
- Thromboxane mediation of cardiopulmonary effects of embolism.J Clin Invest. 1982; 70: 361-369
- Measurement of pulmonary edema.Circ Res. 1965; 16: 482-488
- Assay for lipid peroxidation in animal tissues by thiobarbituric acid reaction.Anal Biochem. 1979; 95: 351-358
- Quantitative bacteriology and delayed wound closure.Surg Forum. 1968; 19: 501-502
- Effect of topically applied steroidal and nonsteroidal anti-inflammatory agents on skin repair and regeneration.Fed Proc. 1984; 43: 2793-2798
- Distribution and oxidation of malondialdehyde in mice.Prostaglandins. 1985; 30: 241-254
- Tumor necrosis factor provokes superoxide anion generation from neutrophils.Biochem Biophys Res Commun. 1986; 137: 1094-1100
- Endotoxin causes hydrogen peroxide induced lung lipid peroxidation and prostanoid production.Arch Surg. 1988; 123: 1337-1341
- The role of lipid peroxidation in endotoxin induced hepatic damage and the protective effect of antioxidants.Surgery. 1987; 101: 746-752
- The delayed and prolonged vascular leakage in inflammation.in: An electron microscope study of the vascular response after thermal injury. 2nd ed. Am J Pathol. 46. 1965: 589-620
- Muscle blood flow following thermal injury.Ann Surg. 1978; 188: 778-786
- The influence of the burn wound on local and systemic response to injury.Ann Surg. 1977; 186: 444-456
- Roles of thermal injury induced hypoproteinemia on fluid flux and protein permeability in burned and nonburn tissue.Surgery. 1984; 95: 136-144
Accepted: August 2, 1990
☆Supported by National Institutes of Health grant GM36428.
© 1991 Published by Elsevier Inc.