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Abstract
We studied the effect of the topical application of the nonsteroidal anti-inflammatory
agent, flurbiprofen, on postburn hypermetabolism and systemic lipid peroxidation.
Twelve sheep with a 15% total body surface third-degree burn were monitored over a
4-day postburn period. In six sheep, a single application of a 5% flurbiprofen cream
was placed on the burn wound on day 3. Data were compared to both burned and nonburned
controls (n = 6). All animals were killed on day 4. Oxygen consumption was increased
at day 3 by 28% ± 10% over the preburn value in all animals. Flurbiprofen significantly
attenuated the increase in oxygen consumption, returning the value essentially to
baseline by 12 hours after application. Lung and liver peroxidation, as measured by
malondialdehyde, was significantly increased in the burned, nontreated sheep at day
4 from a control value of 45 ± 9 and 110 ± 12 to 60 ± 6 and 310 ± 71 nmol/gm tissue,
respectively. In flurbiprofen-treated animals, values were 42 ± 8 and 160 ± 18 nmol/gm
at day 4, significantly attenuated from burn alone. Protein-rich burn lymph flow remained
fourfold increased in both groups, indicating a persistent increase in burn tissue
vascular permeability, not modified by flurbiprofen. Burn wound biopsies revealed
bacterial contents of less than 104 organisms/gram tissue in all animals. We conclude that topical flurbiprofen significantly
decreases burn wound-induced systemic hypermetabolism and oxidant-induced lipid peroxidation
seen at 3 days after burn injury, but does not attenuate the remaining local burn-wound
vascular permeability.
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Article info
Publication history
Accepted:
August 2,
1990
Footnotes
☆Supported by National Institutes of Health grant GM36428.
Identification
Copyright
© 1991 Published by Elsevier Inc.
