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Abstract
A patient is presented with unilobar biliary obstruction associated with marked liver
atrophy and compensatory hypertrophy. Characteristically she was not jaundiced and
had no portal hypertension. Quantitative measurements of the degree of hepatocyte
hyperplasia showed that over 50% of cells in the hypertrophied lobe were hyperplastic.
Surprisingly, a similar percentage of cells in the atrophied lobe were also hyperplastic.
No difference was found in the size of hepatocytes between the two lobes or among
the hepatocyte subpopulations in the atrophied lobe. The findings in this case suggest
(1) lobar atrophy induces a hyperplastic response in more than one half of the cells
of the contralateral lobe; (2) the development of atrophy consequent on biliary obstruction
is likely the result of destruction of whole cells rather than cytoplasmic loss; (3)
the development of a hyperplastic response within the atrophied lobe is a new finding
and is consistent with the hormonal theory of hepatic regeneration; and (4) striking
compensatory hypertrophy of the liver is associated with normal portal venous pressure.
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Article info
Publication history
Accepted:
June 8,
1990
Identification
Copyright
© 1991 Published by Elsevier Inc.
