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Abstract
To develop a new drug delivery system for the treatment of carcinomatous peritonitis,
we constructed 5-fluorouracil poly L-microcapsules (5Fu-mc) by the organic phase separation
technique and examined their drug-releasing capacities and anticancer effects. The
microcapsules consisted of in vitro dissolvable polymolecular poly L-lactic acid and
5-fluorouracil (5Fu). The 5Fu-mc was about 200 μm in diameter and had a 5Fu content
of about 40% (weight/weight). 5Fu-release time from the microcapsules was about 50
hours in vitro and about 48 hours in vivo. After the release of the 5Fu, the poly
L-lactic acid was metabolized very slowly in the peritoneal cavity. The 5Fu-mc caused
fewer side effects than the equivalent dose of a 5Fu solution. In addition, macroscopic
and microscopic examinations of various abdominal organs revealed no toxic effects
from the microcapsules. After administration of 5Fu-mc into the abdominal cavity of
rats with AH-130 carcinomatous peritonitis, the 5Fu concentration remained at a high
level for an extended period in the ascites but fell rapidly to low levels in the
plasma. In conclusion, the present studies indicated that the 5Fu-mc were much more
effective in prolonging the life of tumor-bearing hosts while producing less systemic
side effects than a 5Fu solution.
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References
- Kinetics of tumor growth and of cell proliferation in U.R.D.T. cancers—therapeutic implications.Laryngoscope. 1975; 85: 1039-1052
- Magnetically responsive microspheres and other cancers for the biophysical targeting of antitumor agents.Adv Pharmacol Chemother. 1979; 6: 212-271
- Role of intramuscular administration of water—in oil emulsions as a method for increasing the delivery of anticancer agents to regional lymphatics.J Pharmacokinet Biopharm. 1977; 5: 225-239
- Targeting of drugs.Nature. 1977; 265: 407-411
- Higuchi T Stella V Pro-drug as novel drug delivery systems. American Chemical Society Publications, Washington1975: 1-115
- Intracavitary 5-fluorouracil in malignant effusions.Arch Intern Med. 1965; 116: 431-433
- Absorption of waterland crystalloid molecules from serous cavities: lymphatics & lymph circulation—physiology & pathology.in: 2nd ed. Pregman press, London1967: 495-501
- Clinical delivery system for intraperitoneal hyperthermic chemotherapy.Cancer Res. 1980; 40: 256-260
- Microencapsulation of mitomycin C for intraarterial infusion chemotherapy.in: 5th ed. Proc Jpn Acad. 54. 1978: 413-417
- Serum albumin beads an injectable biodegenerable system for the sustained release of drugs.Science. 1981; 212: 233-235
- Increased concentration of anticancer agents in regional lymph nodes by fat emulsion with special reference to chemotherapy of metastasis.Jpn J Canc Res. 1973; 64: 345-350
- Antitumor activity of mitomycin C-dextran conjugate against various murine tumors.Jpn J Canc Res. 1981; 72: 226-234
- Preparation and properties of a drug-carrier-antibody conjugate showing selective antibody-directed cytotoxicity in vitro.Int J Cancer. 1983; 31: 661-670
- Selective delivery of high levels of mitomycin C to peritoneal carcinomatosis using a new dosage form.Anticancer Res. 1986; 6: 1161-1164
- Polylactic acid for surgical implants.Arch Surg. 1966; 93: 839-843
- The repair of fractures of the orbital floor using biodegradable polylactic acid.Oral Surg. 1972; 33: 28-43
- A biodegradable intraosseous appliance in the treatment of mandibular fractures.J Oral Surg. 1972; 30: 344-348
- Canine patellar tendon replacement with a polylactic acid polymer-filamentous carbon degrading scaffold to form new tissue.Orthop Rev. 1981; 10: 41-45
- Degradation rats of oral resorbable implants (polylactates and polyglycolates)—rats modification with changes inJ Biomed Mater Res. 1977; 11: 711-719
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copolymer ratios. - The synthesis of 5-Fluoro-pyrimidines.J An Chem Soc. 1967; 79: 4559-5460
- Five years clinical experience with 5-fluorouracil.J A M A. 1962; 181: 295-299
- Experimental and clinical use of fluorinated pyrimidines in cancer chemotherapy.Cancer Res. 1963; 23: 1226-1243
- Diffusion of pyrimethamine from silicone rubber and flexible epoxy drug capsules.J Biomed Mater Res. 1973; 7: 193-200
copolymer ratios.Article info
Publication history
Accepted:
June 25,
1990
Identification
Copyright
© 1991 Published by Elsevier Inc.
