This paper is only available as a PDF. To read, Please Download here.
Abstract
This study was performed to determine the extent to which intestinal transplants undergo
functional and morphologic compensation. Animals were studied after 25 days to document
how rapidly the changes occurred and after 150 days to establish whether the effects
were maintained long term. Lewis isografts and Lewis Brown Norway F1 allograft recipient rats had comparable degrees of morphologic (increased bowel diameter,
crypt depth, and villus height) and functional (absorption of 3H-glucose, 14C-maltose, and cyclosporine) compensation. These changes were already present by day
25 and persisted until at least day 150. The results were independent of the loss
of extrinsic innervation or the intramuscular administration of cyclosporine (5 mg/kg/day).
These observations support the usefulness of segmental intestinal transplantation
in the treatment of surgically induced short bowel syndrome.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Segmental intestinal transplantation in rats with resected entire small bowel, ileocecal valve, and cecum.J Surg Res. 1987; 45: 349-356
- Short segment orthotopic intestinal isografts and allografts in enterectomized rats.Transplantation. 1987; 44: 579-582
- Role of gastrin in gastrointestinal adaptation after small bowel resection.Am J Physiol. 1982; 243: G16-G20
- Compensatory postresectional hyperplasia and starvation atrophy in small bowel: dissociation from endogenous gastrin levels.Gastroenterology. 1977; 72: 890-895
- Pancreatic hyperplasia after small bowel resection in the rat: dissociation from endogenous gastrin levels.Digestion. 1984; 29: 223-230
- Elevated plasma enteroglucagon alone fails to alter distal colonic carcinogenesis in rats.Gastroenterology. 1987; 92: 617-624
- Evidence for a humoral mechanism after small intestinal resection.Gastroenterology. 1983; 84: 902-906
- Stimulation of mucosal growth in the rat ileum by bile and pancreatic secretions after jejunal resection.Gastroenterology. 1977; 73: 524-529
- The importance of luminal factors in neomucosal growth.J Surg Res. 1986; 40: 126-132
- Adrenergic denervation of the hypertrophied gut remnant.Ann Surg. 1971; 176: 633-637
- The effects of cyclosporine on varying segments of small-bowel grafts in the rat.Surgery. 1988; 104: 64-69
- Transplantation of small bowel in the rat: technical and immunological considerations.Surgery. 1971; 70: 693-701
- The effects of size and site of origin of intestinal grafts on rat small-bowel transplantation.Surgery. 1987; 101: 618-622
- Compensation by the residual intestine after intestinal resection in the rat.Gastroenterology. 1977; 72: 692-700
- Intestinal adaptation following extensive resection in the rat.Acta Chir Scand. 1962; 123: 51-56
- Small bowel transplantation: an experimental study.Ann R Coll Surg Engl. 1973; 52: 165-181
- Absorbtion studies in canine jejunal allografts.Ann Surg. 1971; 174: 101-108
- Humoral stimulation of cell proliferation in small bowel after transsection and resection in rats.Gastroenterology. 1978; 75: 249-254
- Nutritional adaptation after small bowel resection in rats.J Nutr. 1974; 104: 994-1001
- Effect of monoclonal antibodies to enteroglucagon on ileal adaptation after proximal small bowel resection.Gut. 1987; 28: 9-14
- Distal small bowel resection increases mucosal permeability in the large intestine.Digestion. 1988; 40: 168-172
- The short bowel syndrome.Endosc Rev. 1988; 5: 47-58
- Adaptive changes in postprandial motility after intestinal resection and bypass.Dig Dis Sci. 1988; 33: 1370-1376
Article info
Publication history
Accepted:
July 23,
1990
Footnotes
☆Supported in part by the Foundation for Surgical Education and Investigation.
Identification
Copyright
© 1991 Published by Elsevier Inc.
