Research Article| Volume 113, ISSUE 5, P479-483, May 1993

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Free radicals and other reactive oxygen metabolites: Clinical relevance and the therapeutic efficacy of antioxidant therapy

  • Gregory B. Bulkley
    Reprint requests: Gregory B. Bulkley, MD, FACS, Mark M. Ravitch Professor of Surgery, Blalock 685, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21287-4685.
    From the Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Md., USA
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        • Bulkley GB
        The role of oxygen free radicals in human disease processes.
        Surgery. 1983; 94: 407-411
        • Reilly PM
        • Schiller HJ
        • Bulkley GB
        Reactive oxygen metabolites in shock.
        in: Wilmore DW Care of the Surgical Patient IV. Scientific American, New York1992: 1-32
        • Reilly PM
        • Schiller HJ
        • Bulkley GB
        Pharmacologic approach to tissue injury mediated by free radicals and other reactive oxygen metabolites.
        Am J Surg. 1991; 161: 488-503
      1. Rangan U, Bulkley GB. Prospects for treatment of free radical-mediated tissue injury. Br Med J (in press).

      2. Bulkley GB. Endothelial xanthine oxidase: a radical transducer of inflammatory signals in the reticuloendothelial system. Br J Surg (in press).

        • Harris ML
        • Schiller HJ
        • Reilly PM
        • Donowitz M
        • Grisham MG
        • Bulkley GB
        Free radicals and other reactive oxygen metabolites in inflammatory bowel disease: cause, consequence or epiphenomenon?.
        Pharmacol Ther. 1992; 53: 375-408