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Abstract
Background. Recent evidence has suggested that the anatomic distribution of malignant lymphomas
may reflect important differences in biologic behavior. To determine if the anatomic
distribution of malignant lymphomas in the lung correlated with the disease course,
we examined the pattern of lung involvement in patients with Hodgkin's and non-Hodgkin's
lymphomas.
Methods. We reviewed the medical records of 651 patients with a diagnosis of malignant lymphoma
and identified 54 patients with histologically documented lung involvement. Based
on radiologic and surgical findings, these patients had lung involvement characterized
as either (1) bronchovascular-lymphangitic, (2) nodular, or (3) alveolar. The pattern
of lung involvement was correlated with clinical manifestations and disease course.
Results. Distinct clinical courses were associated with these three patterns of lung involvement.
In contrast, traditional histopathologic classification did not correlate with the
pattern of lung involvement or the disease course in these 54 patients. An alveolar
pattern of lung involvement was a poor prognostic factor and was associated with a
median survival of ![Math Eq]()
months. Pleural effusions eventually developed in 24 patients and were associated
with a median survival of only 3 months.
months. Pleural effusions eventually developed in 24 patients and were associated
with a median survival of only 3 months.Conclusions. These findings suggest that the anatomic pattern of lung involvement is a measure
of biologic behavior and may be a useful variable in the staging of patients with
malignant lymphoma.
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Article info
Publication history
Accepted:
January 24,
1992
Footnotes
☆Supported by National Institutes of Health grant 09280.
Identification
Copyright
© 1993 Published by Elsevier Inc.
