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Abstract
Background. We investigate the effects of sodium valproate, a γ-aminobutyric acid transaminase
inhibitor, on the clinicophysiologic state after ileoanal anastomosis.
Methods. Twelve patients (five with ulcerative colitis and seven with familial adenomatous
polyposis coli) were studied in a placebo-controlled trial.
Results. Placebo had no effect, but valproate increased the resting anal pressure by 22.4%
and the maximum tolerable pouch volume by 20.7%. It also prolonged pouch emptying
by 47.3%, with an associated improvement in stool frequency and incontinence. These
results suggested that valproate improved both reservoir continence and sphincter
continence.
Conclusions. Only minimal side effects were noted, so the administration of sodium valproate appears
to be a safe and useful adjunct for patients with ileoanal anastomosis in the early
postoperative period.
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Article info
Publication history
Accepted:
February 1,
1992
Footnotes
☆Supported by grants from the Ministry of Education, Science and Culture, and Welfare Ministry, Japan.
Identification
Copyright
© 1993 Published by Elsevier Inc.
