This paper is only available as a PDF. To read, Please Download here.
Abstract
Background. Long-term antiestrogen therapy has been suggested as a possible treatment alternative
for ductal carcinoma in situ (DCIS) of the breast. However, very little information
is available on the distribution of estrogen receptor (ER) and treatment success with
antiestrogen for such lesions.
Methods. Thirty-two formalin-fixed tissue specimens of DCIS from 32 female patients aged 38
to 71 years were evaluated for the presence of ER by an immunoperoxidase technique.
Antigenic sites for ER were exposed by treating the tissue sections with deoxyribonuclease
followed by peroxidase-antiperoxidase staining with monoclonal antibody against ER.
Parallel negative controls were run with negative control monoclonal antibody and
normal rat serum. The quality control for positive staining was performed with tissue
sections from specimens with known ER detected by the radioreceptor method.
Results. Eighteen (60%) of the 32 lesions were positive for ER. In 7 of the 18 lesions less
than 25% of cells stained positive for ER and in 4 of the 18 more than 50% of cells
stained positive for ER.
Conclusions. The incidence of ER in DCIS is similar to the incidence of ER in invasive carcinoma,
leading to the speculation that ER-positive invasive carcinoma originates from an
ER-positive precursor lesion. Because only 60% of the cases have detectable ER and
approximately 70% of positively stained ERs are expected to be functional (as in invasive
carcinoma), it appears that approximately 42% of the patient population with DCIS
will benefit from antiestrogen therapy.
To read this article in full you will need to make a payment
Purchase one-time access:
Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online accessOne-time access price info
- For academic or personal research use, select 'Academic and Personal'
- For corporate R&D use, select 'Corporate R&D Professionals'
Subscribe:
Subscribe to SurgeryAlready a print subscriber? Claim online access
Already an online subscriber? Sign in
Register: Create an account
Institutional Access: Sign in to ScienceDirect
References
- Breast cancer detection demonstration project: five-year summary report.Cancer. 1982; 32: 194-225
- Breast carcinoma in situ (CIS): greater rise in ductal carcinoma in situ (DCIS) vs lobular carcinoma in situ (LCIS) [Abstract].in: 2nd ed. Proc Am Soc Clin Oncol. 10. 1991: 45
- Extent of distribution and mammographic histologic correlation of breast ductal carcinoma in situ.Lancet. 1991; 335: 519-522
- Intraductal carcinoma; longterm follow-up after treatment by biopsy alone.J Am Med Assoc. 1978; 239: 1863-1867
- Intraductal carcinoma of breast: follow-up after biopsy only.Cancer. 1982; 49: 751-758
- The clinical significance of preinvasive breast carcinoma.Cancer. 1980; 46: 909-925
- Ductal carcinoma in situ (intraductal carcinoma) of the breast.N Engl J Med. 1988; 318: 898-903
- Treatment and survival of female patients with non-palpable breast cancer.Ann Surg. 1989; 209: 245-253
- In situ carcinoma of the female breast: incidence, clinical finding and DBCA proposal for management.Acta Oncol. 1988; 27: 679-682
- Conservative surgery and radiotherapy (CS and RT) for ductal carcinoma in situ (DCIS) [Abstract].in: 2nd ed. Proc Am Soc Clin Oncol. 10. 1991: 47
- Future direction of adjuvant and preventive therapy of breast cancer.Rev Endocr Rel Cancer. 1987; 27: 11-15
- The prevention of breast cancer.Lancet. 1986; 2: 83-86
- The control of hormone dependent breast cancer growth: are we talking about estrogen alone?.Eur J Cancer Clin Oncol. 1988; 24: 1245-1248
- Detection of estrogen receptors with monoclonal antibodies in routinely processed formalin fixed paraffin sections of breast carcinoma.Am J Clin Pathol. 1987; 87: 161-167
- Cancer of the breast.in: DeVita VT Hellman S Rosenberg SA Cancer principles and practice of oncology. JB Lippincott, Philadelphia1982: 914-970
- Therapeutic use of tamoxifen in advanced breast cancer: correlation with biochemical parameters.Cancer Treat Rep. 1976; 60: 1437-1443
- Use of monoclonal antibody for assessment of estrogen receptor content in fine needle aspiration biopsy specimen from patients with breast cancer.Arch Pathol Lab Med. 1989; 113: 26-30
- Potential value of hormone receptor assay in carcinoma in situ of breast.Am J Clin Pathol. 1990; 94: 533-537
- Hormones in breast carcinoma.Metabolism. 1978; 27: 487-501
- The histopathologist evaluation of human breast cancers in correlation with estrogen receptor value.Cancer. 1980; 46: 362-387
- Tamoxifen (antiestrogen) therapy in advanced breast cancer.Ann Intern Med. 1977; 87: 687-690
- Prognostic significance of estrogen regulated protein, cathepsin D, in breast cancer.Cancer. 1990; 65: 265-271
Article info
Publication history
Accepted:
October 4,
1991
Identification
Copyright
© 1993 Published by Elsevier Inc.
