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Abstract
In a recent study, reperfusion mucosal injury was demonstrated in a rat model of total
ischemia if venous congestion was avoided. The aims were to examine the possibility
of reperfusion damage in a canine model involving 2 hours of complete segmental ischemia
and to investigate the effects of antioxidant therapy or pretreatment with nonspecific
phospholipase A2 inhibitors on postocclusive mucosal changes. Tissue samples were evaluated histologically
in a blind manner, according to a 0 to V grade scale. The degree of mucosal damage
was statistically significantly increased during the 30-minute reperfusion period.
Similarly, 2 hours of total ischemia followed by 30 minutes of reperfusion produced
significantly more tissue lesions than did ![Math Eq]()
hours of ischemia without reperfusion. Oral allopurinol pretreatment supplemented
by an intravenous dose, or oral allopurinol in combination with a superoxide radical
scavenger, resulted in a significant amelioration of postischemic histologic changes.
Pretreatment with a nonspecific phospholiphase A2 inhibitor (methylprednisolone, dexamethasone, or quinacrine) was ineffective in diminishing
the reperfusion injury in either case. The results suggest that reperfusion injury
may develop even after complete intestinal ischemia, and this damage can be attenuated
by inhibiting the capacity of xanthine oxidase to generate reactive oxygen intermediates.
hours of ischemia without reperfusion. Oral allopurinol pretreatment supplemented
by an intravenous dose, or oral allopurinol in combination with a superoxide radical
scavenger, resulted in a significant amelioration of postischemic histologic changes.
Pretreatment with a nonspecific phospholiphase A2 inhibitor (methylprednisolone, dexamethasone, or quinacrine) was ineffective in diminishing
the reperfusion injury in either case. The results suggest that reperfusion injury
may develop even after complete intestinal ischemia, and this damage can be attenuated
by inhibiting the capacity of xanthine oxidase to generate reactive oxygen intermediates.To read this article in full you will need to make a payment
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Article info
Publication history
Accepted:
October 30,
1991
Footnotes
☆Supported by research grants OTKA 1336 and ETT Eü.M. T-67/1990.
Identification
Copyright
© 1993 Published by Elsevier Inc.
