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Abstract
Twenty consecutive cases of Fournier's gangrene managed conservatively with systemic
antibiotics and topical application of unprocessed honey (group A) were compared with
21 similar cases of Fournier's gangrene managed by the orthodox method (group B) during
the same period. Group A received oral amoxicillin/clavulanic acid and metronidazole
in addition to daily topical application of honey to the gangrenous scrotum, whereas
group B underwent wound d'ebridement, wound excision, secondary suturing, and in some
cases scrotal plastic reconstruction in addition to receiving a mixture of systemic
antibiotics dictated by culture and sensitivity results. The organisms cultured in
both groups were similar. Even though the average duration of hospitalization was
slightly longer in group A (4.5 weeks) as opposed to group B (4 weeks), topical application
of honey showed distinct advantages over the orthodox method. Three deaths occurred
in group B, whereas no deaths occurred in group A. The need for anesthesia and expensive
surgical operation was obviated. Response to treatment and alleviation of morbidity
were faster in group A. Honey may revolutionize the treatment of this dreadful disease
by reducing morbidity and mortality.
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Article info
Publication history
Accepted:
December 2,
1991
Identification
Copyright
© 1993 Published by Elsevier Inc.
