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Abstract
Background. Intestinal infusion of leucine augments the maximal gastric-acid secretory response
to pentagastrin and serves as a bioassay for intestinal-phase acid secretion. Another
action of leucine is to decrease tyrosine flux into neural tissues. We hypothesized
that the mechanism of leucine-stimulated acid secretion involves its ability to alter
tyrosine absorption.
Methods. We administered tyrosine intrajejunally and intravenously to anesthetized, vagotomized
rats during maximal pentagastrin stimulation and measured acid output in response
to intrajejunal infusion of leucine.
Results. Intrajejunal tyrosine produced a dose-dependent inhibition of leucine-stimulated
acid secretion but only mild effects on acid secretion in response to pentagastrin
alone. Intravenous tyrosine infusions also decreased acid secretion in response to
intestinal leucine but required much higher doses.
Conclusions. Tyrosine exerts a specific inhibitory effect on leucine-stimulated acid secretion,
which is mediated intraluminally. Because tyrosine is an important regulator of adrenergic
nervous system activity, we speculate that the mechanism of leucine-stimulated acid
secretion may involve modulation of the sympathetic nervous system, thereby affecting
acid secretion.
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Article info
Publication history
Accepted:
August 16,
1992
Footnotes
☆A portion of the data was presented in poster form at the annual meeting of the Association for Academic Surgery, Houston, Texas, Nov. 14–17, 1990.
Identification
Copyright
© 1993 Published by Elsevier Inc.
