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Abstract
Background. Many studies have analyzed the metastatic patterns of breast carcinoma. However,
very few studies have analyzed the differences in metastatic patterns of lobular versus
ductal carcinoma.
Methods. By use of our tumor registry, the metastatic sites of all invasive lobular and invasive
ductal breast carcinoma cases during an 18-year period (January 1973 to December 1990)
were analyzed.
Results. There were 2605 cases of invasive lobular and invasive ductal breast carcinoma. Lobular
carcinoma accounted for 359 (14%) and ductal carcinoma for 2246 (86%) of the cases.
The percentage of patients with regional lymph node metastasis at diagnosis was not
significantly different between the two groups. The rates of metastasis to all lymph
nodes, liver, and central nervous system were not significantly different. However,
the rates of metastasis to the gastrointestinal system (4.5% vs 0.2%), gynecologic
organs (4.5% vs 0.8%), peritoneum-retroperitoneum (3.1% vs 0.6%), adrenal glands (0.6%
vs 0%), bone-marrow (21.2% vs 14.4%), and lung-pleura (2.5% vs 10.2%) were significantly
different (p < 0.05).
Conclusions. The metastatic patterns of lobular and ductal carcinoma of the breast are different,
with gastrointestinal system, gynecologic organ, and peritoneum-retroperitoneum metastases
markedly more prevalent in lobular carcinoma. Physicians should be aware of these
different metastatic patterns of lobular and ductal carcinoma of the breast.
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Article info
Footnotes
☆Presented at the Fiftieth Annual Meeting of the Central Surgical Association, Cincinnati, Ohio, March 4–6, 1993.
Identification
Copyright
© 1993 Published by Elsevier Inc.
