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Abstract
Background. Although use of histamine H2 antagonists for chronic treatment of primary hyperparathyroidism (PHP) is ineffective,
pretreatment with cimetidine has been reported to reduce the incidence of postoperative
hypocalcemia in patients with PHP undergoing neck exploratory operation. The current
investigation was conducted to determine the validity of this assertion.
Methods. In a randomized, double-blind, placebo-controlled trial, 20 patients with PHP were
treated with either cimetidine or placebo for 10 to 14 days before neck exploratory
operation. Clinical outcome and biochemical indexes before and after drug treatment
in both groups were compared.
Results. Cimetidine treatment resulted in a modest increase in preoperative parathyroid hormone
level but did not affect any other parameter, including serum calcium level or renal
tubular reabsorption of phosphate. Intraoperative time was similar in both groups.
Mean postoperative calcium nadir was identical regardless of therapy (8.3 mg/dl),
and seven (70%) patients from each group had at least one serum calcium measurement
less than 8.5 mg/dl.
Conclusions. Cimetidine treatment before neck exploratory operation for PHP does not diminish
the frequency or severity of postoperative hypocalcemia.
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Article info
Publication history
Accepted:
February 15,
1992
Footnotes
☆Presented in part at the 1990 Meeting of the Endocrine Society, Atlanta, Ga., June 20–23, 1990.
☆☆The opinions or assertions contained herein are the private view of the authors and are not to be construed as official or as reflecting the views of the U.S. Army or the Department of Defense.
Identification
Copyright
© 1993 Published by Elsevier Inc.
