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Abstract
Background. We studied the expression of chemotactic, opsonic, and adherent receptors on the
membranes of polymorphonuclear neutrophils (PMNs) from surgical patients because modulation
of these receptors has been suggested in the control of critical PMN functions that
directly or indirectly influence patient outcome.
Methods. Healthy subjects who had PMN adherence, chemotaxis, and receptor measurements were
compared with preoperative surgical patients and those who were within 48 hours of
an admission to an intensive care unit (surgical intensive care unit) because of an
acute illness.
Results. The following receptor/cell pattern was found in control subjects, preoperative patients,
and patients in the surgical intensive care unit, respectively: formyl peptide (13,000
vs 18,000 vs 22,000), CR3 (59,000 vs 105,000 vs 121,000), fibronectin (21,000 vs 20,000
vs 35,000), FcIIγ (9,000 vs 20,000 vs 25,000), C5a (347 vs 265 vs 250 mean channel
number), and FcIIIR (64,000 vs 75,000 vs 26,000). This receptor pattern was partly
correlated directly or indirectly with the acute-phase response, neutrophil adherence,
and PMN chemotaxis from these subjects.
Conclusions. The data suggest that there are alterations in the expression and modulation of PMN
surface membrane receptors in patients with a “stable” disease process compared with
those with an acute illness, which may affect critical PMN functions needed to combat
bacterial infections.
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Publication history
Accepted:
February 15,
1992
Footnotes
☆Supported in part by the Medical Research Council of Canada.
Identification
Copyright
© 1993 Published by Elsevier Inc.
