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Abstract
Background. A significant reduction in the serum concentration of triiodothyronine is frequently
observed in surgical stress and may influence the severity and prognosis of the underlying
disease.
Methods. Alterations of thyroid hormone levels and effects of triiodothyronine were evaluated
in the shock state after Pringle's maneuver for 60 minutes in dogs. Triiodothyronine
(1 μg/kg/hr) was infused intravenously for 3 hours after declamping in the triiodothyronine-treated
group. The effect of triiodothyronine on hepatic mitochondrial function was investigated
by measuring the arterial ketone body ratio (AKBR).
Results. In the control group (n = 6) the low triiodothyronine syndrome was observed and progressive
deterioration of AKBR and standard liver functions represented by aspartate aminotransferase,
glutamic-pyruric transaminase, and lactic dehydrogenase were noted after declamping.
All dogs went into shock and died within 24 hours. By contrast, in the triiodothyronine-treated
group (n = 6), hemodynamics were stabilized and standard liver functions were maintained
favorably (p < 0.01). AKBR was fully restored to the preischemic liver within 30 minutes
after declamping, with a decrease in serum lactate levels (p < 0.05). All dogs survived
at least 7 days after operation (p < 0.01).
Conclusions. These results indicate that triiodothyronine has beneficial effects on cytoprotection,
hemodynamics, and hepatic energy metabolism in the ischemic liver injury. Furthermore,
it improves survival in the shock state after Pringle's maneuver.
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Article info
Publication history
Accepted:
February 14,
1992
Footnotes
☆Supported in part by grants from the Scientific Research Fund of the Ministry of Education and a grant-in-aid for cancer research from the Ministry of Health and Welfare, Japan.
Identification
Copyright
© 1993 Published by Elsevier Inc.
